ArticleJournal of molecular biology2016
IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function.
Article in Journal of molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- The vascular endothelium as decision maker in lung injury.Frontiers in cell and developmental biology · 2025Review
- TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells.Nature communications · 2024Article
- Extraordinary diversity of the CD28/CTLA4 family across jawed vertebrates.Frontiers in immunology · 2024Article
- Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy.EBioMedicine · 2022Review
- Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth.Open biology · 2022Review
- A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.Journal of biomedical science · 2021Article
- Cell Adhesion Molecules in Plasticity and Metastasis.Molecular cancer research : MCR · 2021Review
- Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy.The Journal of biological chemistry · 2020Article
- The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress.The Journal of biological chemistry · 2019Article
- Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis.Cells · 2019Review
- CD28 Homolog Is a Strong Activator of Natural Killer Cells for Lysis of B7H7Cancer immunology research · 2019Article
- MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.Journal of molecular cell biology · 2018Article
- TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer.Oncotarget · 2018Article
- Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy.Oncogenesis · 2017Article
- CD28 family of receptors inter-connect in the regulation of T-cells.Receptors & clinical investigation · 2017Article
- Defenders and Challengers of Endothelial Barrier Function.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Endothelial cell (EC) barrier function plays a prevalent regulatory mechanism for the integrity and homeostasis of blood vessels and modulates angiogenesis and immune responses. Cell adhesion molecules (CAMs) play a central role in the barrier function of ECs. Although Ig-containing and proline-rich receptor-1(IGPR-1) was recently identified as a novel CAM expressed in ECs, the molecular mechanisms underlying the function of IGPR-1 in ECs remain uncharacterized. In this report, we investigated the role of IGPR-1 in EC barrier function and the molecular mechanism of its activation in ECs. We demonstrate that IGPR-1 is localized to endothelial adherens junctions and, through trans-homophilic dimerization, regulates endothelial cell-cell adhesion and barrier function. Trans-homophilic dimerization of IGPR-1 stimulates the phosphorylation of serine 220 (Ser220), which is required for IGPR-1 to regulate endothelial barrier function and angiogenesis. Moreover, IGPR-1 chimera, which mimics the trans-homophilic dimerization of IGPR-1, induced a sustained phosphorylation of Ser220 upon stimulation with a ligand. Coordinated dimerization of IGPR-1 and its homophilic interaction modulates its adhesive function and Ser220 phosphorylation. This adhesive function of IGPR-1 contributes to the barrier function of ECs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.