Evidence map›Paper›PMID 27838286›Full record

ArticleNeuroImage2018

Topological false discovery rates for brain mapping based on signal height.

Junning Li, Jin Kyu Gahm, Yonggang Shi, Arthur W Toga

Abstract read
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junning LiLaboratory of Neuro Imaging (LONI), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address: Junning.Li@loni.usc.edu.
Jin Kyu GahmLaboratory of Neuro Imaging (LONI), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address: JinKyu.Gahm@loni.usc.edu.
Yonggang ShiLaboratory of Neuro Imaging (LONI), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address: yonggang.shi@loni.usc.edu.
Arthur W TogaLaboratory of Neuro Imaging (LONI), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address: toga@loni.usc.edu.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
TrainingU54EB020406 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2014 to 2018
$12.5M
Genetic Influences on Human Neuroanatomical ShapesR01MH094343 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2016
$2.4M
Intrinsic Modeling and Tracking of Neuroanatomy in Alzheimer's DiseaseK01EB013633 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHI, YONGGANG · 2012 to 2016
$833k
CIHRNIA NIH HHS P01 AG052350NIA NIH HHS P50 AG005142NIA NIH HHS U01 AG024904NIBIB NIH HHS K01 EB013633NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020406NIMH NIH HHS R01 MH094343
6 · The paper itself

Abstract

Correcting the effect of multiple testing is important in statistical parametric mapping. If the threshold is too liberal, then spurious claims may flood in; if it is too conservative, then true hints may be overlooked. It is highly desirable to combine random field theory and the false discovery rate (FDR) to achieve more powerful detection under gauged topological errors. However, the current FDR method based on peak height does not fully meet this expectation, and sometimes is more conservative than the traditional family-wise error rate method, for unexplained reasons. In this paper, we introduce a new topological FDR method based on signal height. As analyzed in theory and validated with extensive experiments, it controls error rates much more accurately than the peak FDR method does, and substantially gains detection power. In addition, we discover reasons behind the peak FDR method's under-performance, and formulate equations to predict the two methods' behavior.

Indexed as

Models, TheoreticalBrain MappingHumansFalse discovery rateStatistical parametric mapping

Identifiers

PMID27838286
PMCPMC5423870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.