Evidence map›Paper›PMID 27838170›Full record

ArticleBioorganic & medicinal chemistry2017

An evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates.

Aaron L Smith, Hasse Walum, Fawn Connor-Stroud, Sara M Freeman, Kiyoshi Inoue, Lisa A Parr, Mark M Goodman, Larry J Young

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. The Current Status of Drug Discovery for the Oxytocin Receptor.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Review
  5. A Precision Medicine Approach to Oxytocin Trials.Current topics in behavioral neurosciences
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aaron L SmithSilvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA; Center for Systems Imaging, Emory University, 1841 Clifton Road NE, Atlanta, GA 30322, USA. Electronic address: asmit53@emory.edu.
Hasse WalumSilvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Fawn Connor-StroudYerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Sara M FreemanCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.
Kiyoshi InoueSilvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Lisa A ParrSilvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Mark M GoodmanSilvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA; Center for Systems Imaging, Emory University, 1841 Clifton Road NE, Atlanta, GA 30322, USA.
Larry J YoungSilvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Emory University · USUniversity of California, Davis · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Impact of Oxytocin on the Neural Representation Social Stimuli P50MH100023 · NIMH · EMORY UNIVERSITY · PI YOUNG, LARRY J · 2013 to 2022
$21.8M
NIH HHS P51 OD011132NIMH NIH HHS P50 MH100023
6 · The paper itself

Abstract

The physiology of the oxytocin receptor has increasingly become a focus of scientific investigation due to its connection with social behavior and psychiatric disorders with impairments in social funciton. Experimental utilization of small molecule and peptide antagonists for the oxytocin receptor has played a role in deciphering these biological and social behavior connections in rodents. Described herein is the evaluation of a potent and selective oxytocin receptor antagonist, ALS-I-41, and details to consider for its use in nonhuman primate behavioral pharmacology experiments utilizing intranasal or intramuscular administration. The central nervous system penetration and rate of metabolism of ALS-I-41 was investigated via mass spectroscopy analysis of cerebrospinal fluid and plasma in the rhesus macaque after intranasal and intramuscular administration. Positron emission tomography was also utilized with [

Indexed as

Administration, IntranasalAnimalsBrainFemaleFluorine RadioisotopesInjections, IntramuscularMacaca fascicularisMacaca mulattaMalePositron-Emission TomographyQuinolonesRadiopharmaceuticalsRats, Sprague-DawleyReceptors, OxytocinSulfonamidesALS-I-41Fluorine RadioisotopesQuinolonesRadiopharmaceuticalsReceptors, OxytocinSulfonamidesCerebrospinal fluidOxytocin antagonistOxytocin receptorPET imagingRhesus macaque

Identifiers

PMID27838170
PMCPMC5207485
OpenAlexW2548333214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.