ArticlePsychoneuroendocrinology2017
Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep.
Article in Psychoneuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 59 citations in OpenAlex.
- History of and evidence for puberty suppression as intervention for children experiencing gender dysphoria.The Medico-legal journal · 2026Article
- Puberty Suppression for Pediatric Gender Dysphoria and the Child's Right to an Open Future.Archives of sexual behavior · 2024Article
- Puberty suppression in adolescents with gender dysphoria: an emerging issue with multiple implications.Frontiers in endocrinology · 2024Review
- Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2022Article
- Effects of Minocycline on Cognitive Impairment, Hippocampal Inflammatory Response, and Hippocampal Alzheimer's Related Proteins in Aged Rats after Propofol Anesthesia.Disease markers · 2022Article
- An appraisal of current service delivery and future models of care for young people with gender dysphoria.European journal of pediatrics · 2021Article
- On the role of sex steroids in biological functions by classical and non-classical pathways. An update.Frontiers in neuroendocrinology · 2021Review
- Current approach to the clinical care of adolescents with gender dysphoria.Acta bio-medica : Atenei Parmensis · 2020Review
- Deficiencies in Scientific Evidence for Medical Management of Gender Dysphoria.The Linacre quarterly · 2020Article
- Morphological Evidence for Functional Crosstalk Between Multiple GnRH Systems in the Male Tilapia,Frontiers in endocrinology · 2020Article
- Peripubertal GnRH and testosterone co-treatment leads to increased familiarity preferences in male sheep.Psychoneuroendocrinology · 2019Article
- Gender affirming medical care of transgender youth.Current problems in pediatric and adolescent health care · 2019Article
- Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior.Psychology research and behavior management · 2019Review
- A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep.Psychoneuroendocrinology · 2017Article
- Brain Maturation, Cognition and Voice Pattern in a Gender Dysphoria Case under Pubertal Suppression.Frontiers in human neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic gonadotropin-releasing hormone agonist (GnRHa) is used therapeutically to block activity within the reproductive axis through down-regulation of GnRH receptors within the pituitary gland. GnRH receptors are also expressed in non-reproductive tissues, including areas of the brain such as the hippocampus and amygdala. The impact of long-term GnRHa-treatment on hippocampus-dependent cognitive functions, such as spatial orientation, learning and memory, is not well studied, particularly when treatment encompasses a critical window of development such as puberty. The current study used an ovine model to assess spatial maze performance and memory of rams that were untreated (Controls), had both GnRH and testosterone signaling blocked (GnRHa-treated), or specifically had GnRH signaling blocked (GnRHa-treated with testosterone replacement) during the peripubertal period (8, 27 and 41 weeks of age). The results demonstrate that emotional reactivity during spatial tasks was compromised by the blockade of gonadal steroid signaling, as seen by the restorative effects of testosterone replacement, while traverse times remained unchanged during assessment of spatial orientation and learning. The blockade of GnRH signaling alone was associated with impaired retention of long-term spatial memory and this effect was not restored with the replacement of testosterone signaling. These results indicate that GnRH signaling is involved in the retention and recollection of spatial information, potentially via alterations to spatial reference memory, and that therapeutic medical treatments using chronic GnRHa may have effects on this aspect of cognitive function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.