Evidence map›Paper›PMID 27837663›Full record

ReviewCurrent opinion in neurobiology2017

MicroRNA function in Drosophila memory formation.

Germain U Busto, Tugba Guven-Ozkan, Ronald L Davis

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020
    Review
  5. Article
  6. TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  7. Synaptic Spinules in the Olfactory Circuit ofFrontiers in cellular neuroscience · 2018
    Article
  8. Bioscience reports · 2017
    Article
  9. Article
  10. Review
  11. Neural plasticity · 2017
    Review
  12. eNeuro
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Germain U BustoDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USA.
Tugba Guven-OzkanDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USA.
Ronald L DavisDepartment of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USA. Electronic address: rdavis@scripps.edu.
Scripps Research Institute · US

Funding

Biology of memoryR35NS097224 · NINDS · UNIVERSITY OF FLORIDA · PI DAVIS, RONALD L · 2017 to 2024
$9.1M
Regulation of sleep by microRNAsP01NS090994 · NINDS · HARVARD MEDICAL SCHOOL · PI GRIFFITH, LESLIE C · 2016 to 2020
$5.7M
NINDS NIH HHS P01 NS090994NINDS NIH HHS R35 NS097224
6 · The paper itself

Abstract

MicroRNAs (miRs) are small non-coding RNAs that regulate protein expression through post-transcriptional mechanisms. They participate in broad aspects of biology from the control of developmental processes to tumorigenesis. Recent studies in Drosophila show that they also regulate activity-dependent and sensory-specific protein expression and support olfactory memory formation. Among the hundreds of miRs described, several have been demonstrated to be required for normal learning, memory, or for the development of neuronal circuits that support memory formation. Fly models of human diseases offer promise of identifying miRs whose expression becomes dysregulated and part of the pathological state, providing models for understanding brain disorders and drug discovery.

Indexed as

AnimalsDrosophilaLearningMemoryMicroRNAsModels, AnimalMicroRNAs

Identifiers

PMID27837663
PMCPMC5423858
OpenAlexW2551414009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.