ArticleEuropean journal of psychotraumatology2016
Investigating epigenetic consequences of early-life adversity: some methodological considerations.
Article in European journal of psychotraumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Childhood trauma and adolescent substance use: an integrative perspective.Future science OA · 2025Article
- Genomic insights into genes expressed specifically during infancy highlight their dominant influence on the neuronal system.BMC genomics · 2024Article
- Early life adversity drives sex-dependent changes in 5-mC DNA methylation of parvalbumin cells in the prefrontal cortex in rats.bioRxiv : the preprint server for biology · 2024Article
- Poverty Status at Birth Predicts Epigenetic Changes at Age 15.Journal of biomedical and life sciences · 2024Article
- Resource scarcity but not maternal separation provokes unpredictable maternal care sequences in mice and both upregulateNeurobiology of stress · 2022Article
- Addressing the biological embedding of early life adversities (ELA) among adults through mindfulness: Proposed mechanisms and review of converging evidence.Neuroscience and biobehavioral reviews · 2022Review
- Sleep and Methylation of Estrogen Receptor Genes,Nature and science of sleep · 2020Article
- Childhood maltreatment and risk for suicide attempts in major depression: a sex-specific approach.European journal of psychotraumatology · 2019Article
- Interdisciplinary approaches to understand traumatic stress as a public health problem.European journal of psychotraumatology · 2017Article
- Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders.European journal of psychotraumatology · 2017Article
- The neurobiology of PTSD.European journal of psychotraumatology · 2017Article
- Back to Basics: Integrating Clinical and Scientific Knowledge to Advance the Field of Trauma-Highlights of the ISTSS-2015.European journal of psychotraumatology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Stressful and traumatic events occurring during early childhood have been consistently associated with the development of psychiatric disorders later in life. This relationship may be mediated in part by epigenetic mechanisms, such as DNA methylation, which are influenced by the early-life environment. Epigenetic patterns can have lifelong effects on gene expression and on the functioning of biological processes relevant to stress reactivity and psychopathology. Optimization of epigenetic research activity necessitates a discussion surrounding the methodologies used for DNA methylation analysis, selection of tissue sources, and timing of psychological and biological assessments. Recent studies related to early-life adversity and methylation, including both candidate gene and epigenome-wide association studies, have drawn from the variety of available techniques to generate interesting data in the field. Further discussion is warranted to address the limitations inherent to this field of research, along with future directions for epigenetic studies of adversity-related psychopathology.
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