ReviewEuropean journal of psychotraumatology2016
Unique neurobiology during the sensitive period for attachment produces distinctive infant trauma processing.
Review in European journal of psychotraumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Is neglect the first form of threat?Attachment & human development · 2025Review
- Reconsidering the nature of threat in infancy: Integrating animal and human studies on neurobiological effects of infant stress.Neuroscience and biobehavioral reviews · 2024Review
- Maternal Childhood Abuse Versus Neglect Associated with Differential Patterns of Infant Brain Development.Research on child and adolescent psychopathology · 2023Article
- Linking maternal disrupted interaction and infant limbic volumes: The role of infant cortisol output.Psychoneuroendocrinology · 2023Article
- Early life adversity affecting the attachment bond alters ventral tegmental area transcriptomic patterning and behavior almost exclusively in female mice.Neurobiology of stress · 2021Article
- How Our Caregivers Shape Who We Are: The Seven Dimensions of Attachment at the Core of Personality.Frontiers in psychology · 2021Article
- Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission.Development and psychopathology · 2020Article
- Defining Immediate Effects of Sensitive Periods on Infant Neurobehavioral Function.Current opinion in behavioral sciences · 2020Article
- An Animal Model for Mammalian Attachment: Infant Titi Monkey (Frontiers in psychology · 2020Article
- Using a Developmental Ecology Framework to Align Fear Neurobiology Across Species.Annual review of clinical psychology · 2019Review
- Infant Trauma Alters Social Buffering of Threat Learning: Emerging Role of Prefrontal Cortex in Preadolescence.Frontiers in behavioral neuroscience · 2019Article
- Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation.Frontiers in behavioral neuroscience · 2019Article
- Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior.Developmental cognitive neuroscience · 2017Review
- Back to Basics: Integrating Clinical and Scientific Knowledge to Advance the Field of Trauma-Highlights of the ISTSS-2015.European journal of psychotraumatology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTrauma has neurobehavioral effects when experienced at any stage of development, but trauma experienced in early life has unique neurobehavioral outcomes related to later life psychiatric sequelae. Recent evidence has further highlighted the context of infant trauma as a critical variable in determining its immediate and enduring consequences. Trauma experienced from an attachment figure, such as occurs in cases of caregiver child maltreatment, is particularly detrimental.
methodsUsing data primarily from rodent models, we review the literature on the interaction between trauma and attachment in early life, which highlights the role of the caregiver's presence in engagement of attachment brain circuitry and suppressing threat processing by the amygdala. We then consider how trauma with and without the caregiver produces long-term changes in emotionality and behavior, and suggest that these experiences initiate distinct pathways to pathology.
resultsTogether these data suggest that infant trauma processing and its enduring effects are impacted by both the immaturity of brain areas for processing trauma and the unique functioning of the early-life brain, which is biased toward processing information within the attachment circuitry.
conclusionAn understanding of developmental differences in trauma processing as well as the critical role of the caregiver in further altering early life brain processing of trauma is important for developing age-relevant treatment and interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.