Evidence map›Paper›PMID 27837344›Full record

Trial reportClinical oral investigations2017

Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study.

Takuya Asaka, Noritaka Ohga, Yutaka Yamazaki, Jun Sato, Chiharu Satoh, Yoshimasa Kitagawa

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Interventions for managing medication-related osteonecrosis of the jaw.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Interventions for managing medication-related osteonecrosis of the jaw.The Cochrane database of systematic reviews · 2017
    Pooled it
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  11. Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takuya AsakaDepartment of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan. asakatakuya@den.hokudai.ac.jp.ORCID http://orcid.org/0000-0001-8240-3441
Noritaka OhgaDepartment of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Yutaka YamazakiDepartment of Gerodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
Jun SatoDepartment of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Chiharu SatohDepartment of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Yoshimasa KitagawaDepartment of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of the present study was to evaluate the effectiveness of platelet-rich fibrin (PRF) as a wound-healing accelerator in patients undergoing oral bisphosphonate therapy and requiring tooth extractions. MATERIALS AND

methodsA total of 102 patients were divided into a PRF group and control group. The patients received oral bisphosphonate therapy for osteoporosis for an average of 32 months. Blood was collected and PRF was introduced into the socket of the PRF group only. Monitoring of mucosal healing was conducted for 3 months in both groups, and radiographic evaluation in the sockets was performed in the PRF group. Delayed recovery was defined as exposed bone and vulnerable granulation tissue without epithelization after 4 weeks and resolving by 8 weeks.

resultsThere were no intraoperative complications, and none of the patients exhibited onset of medication-related osteonecrosis of the jaw (MRONJ). Delayed recovery was observed in 9 out of 73 control patients (12%), whereas 29 PRF patients exhibited complete epithelialization of the socket within 1 month. The prevalence of delayed recovery was significantly higher in the control group than the PRF group (P < 0.05). Multivariate logistic regression analysis revealed that risk factors and use of PRF were independent significant factors to relate to delayed recovery (P = 0.02).

conclusionsEarly epithelization was confirmed in all PRF patients. Thus, PRF may reduce the risk of delayed recovery in patients undergoing oral bisphosphonate therapy. CLINICAL RELEVANCE: PRF may be useful in preventing MRONJ in patients receiving oral bisphosphonate (BP).

Indexed as

Tooth ExtractionAdministration, OralAdultAgedAged, 80 and overBone Density Conservation AgentsDiphosphonatesFemaleHumansMaleMiddle AgedOsteoporosisPlatelet-Rich FibrinTreatment OutcomeWound HealingBone Density Conservation AgentsDiphosphonatesEpithelizationMRONJOral bisphosphonatesPRFTooth extraction

Identifiers

PMID27837344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.