ArticleIntensive care medicine2017
Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study.
Article in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 3 of them syntheses that pooled it.
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Who cites it
161 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials.BMC medicine · 2026Pooled it
- Optimal timing of enteral nutrition initiation in critically ill patients: a network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Probiotic supplementation during antibiotic treatment is unjustified in maintaining the gut microbiome diversity: a systematic review and meta-analysis.BMC medicine · 2023Pooled it
- Impact of fiber-containing enteral nutrition on microbial community dynamics in critically ill trauma patients: a pilot-randomized trial.BMC medicine · 2025Trial
- Short-Chain Fatty Acids in Sepsis: Mechanisms of Action and Therapeutic Advances.Biomedicines · 2026Review
- The Bile Acid-Diet-Microbiome Axis inNutrients · 2026Review
- [Mechanisms of live combinedZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Article
- Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review).International journal of molecular medicine · 2026Review
- Clinical and Culture-Based Predictors of Gut Microbiome Alpha Diversity at the Time of ICU Admission.Critical care explorations · 2026Article
- Can We Identify Severe Dysbiosis at the Bedside?Critical care explorations · 2026Article
- Knowledge, Attitudes, and Practices Regarding Probiotic Use in Enteral Feeding Among Intensive Care Unit Healthcare Professionals.Healthcare (Basel, Switzerland) · 2026Article
- Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections.Intensive care medicine experimental · 2026Article
- Short-Chain Fatty Acids: A Key Modulator of Sepsis-Associated Acute Respiratory Distress Syndrome.Journal of inflammation research · 2026Review
- Gut microbiota dysbiosis in post-cardiac arrest syndrome: mechanisms, clinical implications, and therapeutic perspectives.Frontiers in microbiology · 2026Review
- Sepsis and the diverse organ-gastrointestinal tract axis.World journal of critical care medicine · 2025Review
- Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation.Renal failure · 2025Review
- The emerging role of the gut microbiota in vaccination responses.Gut microbes · 2025Review
- The gastrointestinal microbiome in critical illness: A Clinician's guide to mechanisms, emerging tools, and therapeutic questions.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- Targeting Gut-Lung Crosstalk in Acute Respiratory Distress Syndrome: Exploring the Therapeutic Potential of Fecal Microbiota Transplantation.Pathogens (Basel, Switzerland) · 2025Review
- Article
101 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota in critically ill patients may have a negative influence on key energy resources and immunity. We set out to characterize the fecal microbiota composition in critically ill patients both with and without sepsis and to explore the use of microbiota-derived markers for clinical outcome measurements in this setting.
methodsIn this prospective observational cohort study we analyzed the fecal microbiota of 34 patients admitted to the intensive care unit. Fifteen healthy subjects served as controls. The fecal microbiota was phylogenetically characterized by 16S rRNA gene sequencing, and associations with clinical outcome parameters were evaluated.
resultsA marked shift in fecal bacterial composition was seen in all septic and non-septic critically ill patients compared with controls, with extreme interindividual differences. In 13 of the 34 patients, a single bacterial genus made up >50% of the gut microbiota; in 4 patients this was even >75%. A significant decrease in bacterial diversity was observed in half of the patients. No associations were found between microbiota diversity, Firmicutes/Bacteroidetes ratio, or Gram-positive/Gram-negative ratio and outcome measurements such as complications and survival.
conclusionsWe observed highly heterogeneous patterns of intestinal microbiota in both septic and non-septic critically ill patients. Nevertheless, some general patterns were observed, including disappearance of bacterial genera with important functions in host metabolism. More detailed knowledge of the short- and long-term health consequences of these major shifts in intestinal bacterial communities is needed.
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