ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Middle cerebral artery diameter changes during rhythmic handgrip exercise in humans.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 104 citations in OpenAlex.
- Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Sex-based differences in central and cerebral hemodynamic responses to lower body negative pressure (LBNP): an experimental study.European journal of applied physiology · 2026Article
- Resistance exercise with combined Valsalva manoeuvre acutely increases carotid-femoral pulse wave velocity in healthy untrained individuals.European journal of applied physiology · 2026Article
- Intracranial vasomotor and blood flow responses to light-intensity aerobic exercise in young adults: a 4D flow MRI study.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Impact of exercise on cognitive efficiency in older adults with subjective memory complaints: a randomized clinical trial.Frontiers in aging neuroscience · 2026Article
- No difference in mean middle cerebral artery blood velocity responses between lower- and upper-body unilateral resistance exercise in untrained individuals.Experimental physiology · 2025Article
- Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke.Scientific reports · 2025Observational
- Visual stimulus-evoked blood velocity responses in individual human posterior cerebral arteries measured with dynamic phase-contrast functional MR angiography.bioRxiv : the preprint server for biology · 2025Article
- Regulation of cerebrovascular resistance below the lower limit of cerebral autoregulation during induced hypotension: an observational study.British journal of anaesthesia · 2025Observational
- Larger reductions in blood pressure during post-exercise standing, but not middle cerebral artery blood velocity, in resistance-trained versus untrained individuals.Experimental physiology · 2025Article
- Effect of prolonged sitting on dynamic cerebral autoregulation in the anterior and posterior cerebral circulations.Experimental physiology · 2025Article
- Visual stimulus-evoked blood velocity responses in individual human posterior cerebral arteries measured with dynamic phase-contrast functional MR angiography.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neurovascular coupling during dynamic upper body resistance exercise in healthy individuals.Experimental physiology · 2024Article
- The effects of habitual resistance exercise training on cerebrovascular responses to lower body dynamic resistance exercise: A cross-sectional study.Experimental physiology · 2024Article
- Variability in Intracranial Vessel Diameters and Considerations for Neurovascular Models: A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Comparison of computational fluid dynamics with transcranial Doppler ultrasound in response to physiological stimuli.Biomechanics and modeling in mechanobiology · 2024Article
- Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults.European journal of applied physiology · 2023Article
- Validity of transcranial Doppler ultrasonography-determined dynamic cerebral autoregulation estimated using transfer function analysis.Journal of clinical monitoring and computing · 2022Article
- Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.European journal of applied physiology · 2022Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial Doppler (TCD) sonography is a frequently employed technique for quantifying cerebral blood flow by assuming a constant arterial diameter. Given that exercise increases arterial pressure by sympathetic activation, we hypothesized that exercise might induce a change in the diameter of large cerebral arteries. Middle cerebral artery (MCA) cross-sectional area was assessed in response to handgrip exercise by direct magnetic resonance imaging (MRI) observations. Twenty healthy subjects (11 female) performed three 5 min bouts of rhythmic handgrip exercise at 60% maximum voluntary contraction, alternated with 5 min of rest. High-resolution 7 T MRI scans were acquired perpendicular to the MCA. Two blinded observers manually determined the MCA cross-sectional area. Sufficient image quality was obtained in 101 MCA-scans of 19 subjects (age-range 20-59 years). Mixed effects modelling showed that the MCA cross-sectional area decreased by 2.1 ± 0.8% (p = 0.01) during handgrip, while the heart rate increased by 11 ± 2% (p < 0.001) at constant end-tidal CO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.