ArticlePlant physiology2017
cis-Cinnamic Acid Is a Novel, Natural Auxin Efflux Inhibitor That Promotes Lateral Root Formation.
Article in Plant physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 83 citations in OpenAlex.
- Asparagus Decline and Replant Problem: Autotoxicity, Autotoxic Substances, and Their Biological Functions.Biology · 2026Review
- Nature's laboratory: plant metabolic engineering methods using phenylpropanoids as a case study.Biotechnology for biofuels and bioproducts · 2025Review
- Unveiling the root-rhizosphere environment of perennial wheat: a metabolomic perspective.BMC plant biology · 2025Article
- Isolation and identification of allelochemicals and their activities and functions.Journal of pesticide science · 2024Article
- Antifungal mechanism of volatile compounds emitted bymSphere · 2023Article
- Hormonal and proteomic analyses of southern blight disease caused byPlant direct · 2023Article
- Pinoresinol rescues developmental phenotypes of Arabidopsis phenylpropanoid mutants overexpressingProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effects of chitin and chitosan on root growth, biochemical defense response and exudate proteome ofPlant-environment interactions (Hoboken, N.J.) · 2023Article
- Design and synthesis of strong root gravitropism inhibitors with no concomitant growth inhibition.Scientific reports · 2023Article
- Structure-Activity Relationship (SAR) Study ofPlants (Basel, Switzerland) · 2023Article
- Short-Term Effects ofPlants (Basel, Switzerland) · 2023Article
- Modulation of lignin biosynthesis for drought tolerance in plants.Frontiers in plant science · 2023Review
- Opposing effects ofPlant direct · 2022Article
- ThePlants (Basel, Switzerland) · 2022Article
- A New Series of Strigolactone Analogs Derived From Cinnamic Acids as Germination Inducers for Root Parasitic Plants.Frontiers in plant science · 2022Article
- Lessons Learned from the Studies of Roots Shaded from Direct Root Illumination.International journal of molecular sciences · 2021Review
- The Steroid Saponin Protodioscin ModulatesPlants (Basel, Switzerland) · 2021Article
- Chemical Biology in Auxin Research.Cold Spring Harbor perspectives in biology · 2021Review
- Behind the Scenes: The Impact of Bioactive Phenylpropanoids on the Growth Phenotypes of Arabidopsis Lignin Mutants.Frontiers in plant science · 2021Article
- Phenylpropanoids Are Connected to Cell Wall Fortification and Stress Tolerance in Avocado Somatic Embryogenesis.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 7 countries.
Funding
Abstract
Auxin steers numerous physiological processes in plants, making the tight control of its endogenous levels and spatiotemporal distribution a necessity. This regulation is achieved by different mechanisms, including auxin biosynthesis, metabolic conversions, degradation, and transport. Here, we introduce cis-cinnamic acid (c-CA) as a novel and unique addition to a small group of endogenous molecules affecting in planta auxin concentrations. c-CA is the photo-isomerization product of the phenylpropanoid pathway intermediate trans-CA (t-CA). When grown on c-CA-containing medium, an evolutionary diverse set of plant species were shown to exhibit phenotypes characteristic for high auxin levels, including inhibition of primary root growth, induction of root hairs, and promotion of adventitious and lateral rooting. By molecular docking and receptor binding assays, we showed that c-CA itself is neither an auxin nor an anti-auxin, and auxin profiling data revealed that c-CA does not significantly interfere with auxin biosynthesis. Single cell-based auxin accumulation assays showed that c-CA, and not t-CA, is a potent inhibitor of auxin efflux. Auxin signaling reporters detected changes in spatiotemporal distribution of the auxin response along the root of c-CA-treated plants, and long-distance auxin transport assays showed no inhibition of rootward auxin transport. Overall, these results suggest that the phenotypes of c-CA-treated plants are the consequence of a local change in auxin accumulation, induced by the inhibition of auxin efflux. This work reveals a novel mechanism how plants may regulate auxin levels and adds a novel, naturally occurring molecule to the chemical toolbox for the studies of auxin homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.