ArticleJournal of lipid research2017
Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 20 citations in OpenAlex.
- The Lipid Droplet-Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children.Obesity (Silver Spring, Md.) · 2026Article
- Potential of marine dinoflagellates Amphidinium carterae and Prorocentrum minimum as fatty acids producers: A comparative transcriptome and fatty acid profiling study.Journal of microbiology (Seoul, Korea) · 2026Article
- From Storage to Signaling: Lipid Droplet Lipolysis in Cholesterol Mobilization and Foam Cell Remodeling.Current atherosclerosis reports · 2026Review
- Mitochondria-ER crosstalk via MAMS: Bridging cellular homeostasis and cancer progression.Apoptosis : an international journal on programmed cell death · 2026Review
- Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance.Oncogenesis · 2025Article
- Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases.Chinese medicine · 2024Review
- Lipid droplet-associated hydrolase mobilizes stores of liver X receptor sterol ligands and protects against atherosclerosis.Nature communications · 2024Article
- Host genetics and gut microbiota jointly regulate blood biochemical indicators in chickens.Applied microbiology and biotechnology · 2023Article
- Mitochondria-associated endoplasmic reticulum membrane: Overview and inextricable link with cancer.Journal of cellular and molecular medicine · 2023Review
- A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk.International journal of cancer · 2022Article
- The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting.Trends in biochemical sciences · 2022Review
- Lipolysis: cellular mechanisms for lipid mobilization from fat stores.Nature metabolism · 2021Review
- Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.Developmental cell · 2020Article
- Going through a phase.Nature chemical biology · 2020Article
- Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response.Cell cycle (Georgetown, Tex.) · 2019Article
- SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in aDisease models & mechanisms · 2019Article
- Loss of LDAH associated with prostate cancer and hearing loss.Human molecular genetics · 2018Article
- Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis.ACS chemical biology · 2018Article
- Lipid Droplet-Associated Hydrolase Promotes Lipid Droplet Fusion and Enhances ATGL Degradation and Triglyceride Accumulation.Scientific reports · 2017Article
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
Variations in the gene LDAH (C2ORF43), which encodes lipid droplet-associated hydrolase (LDAH), are among few loci associated with human prostate cancer. Homologs of LDAH have been identified as proteins of lipid droplets (LDs). LDs are cellular organelles that store neutral lipids, such as triacylglycerols and sterol esters, as precursors for membrane components and as reservoirs of metabolic energy. LDAH is reported to hydrolyze cholesterol esters and to be important in macrophage cholesterol ester metabolism. Here, we confirm that LDAH is localized to LDs in several model systems. We generated a murine model in which Ldah is disrupted but found no evidence for a major function of LDAH in cholesterol ester or triacylglycerol metabolism in vivo, nor a role in energy or glucose metabolism. Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer.
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