ArticleBMJ open2016
Hospital-diagnosed atopic dermatitis and long-term risk of myocardial infarction: a population-based follow-up study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies.The Journal of allergy and clinical immunology · 2019Pooled it
- Relationship of atopic dermatitis with stroke and myocardial infarction: A meta-analysis.Medicine · 2018Pooled it
- Cardiovascular risk among middle-aged Japanese adults with atopic dermatitis: A nested case-control study.PloS one · 2026Article
- Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato-venereologists.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Atopic Dermatitis and the Risk of Myocardial Infarction and All-Cause Mortality: A Nationwide Population-Based Cohort Study.Allergy, asthma & immunology research · 2023Article
- Proteomic characterization of atopic dermatitis blood from infancy to adulthood.Journal of the American Academy of Dermatology · 2023Observational
- Incidence of Cardiovascular Disease After Atopic Dermatitis Development: A Nationwide, Population-Based Study.Allergy, asthma & immunology research · 2023Article
- A Review of Safety Outcomes from Clinical Trials of Baricitinib in Rheumatology, Dermatology and COVID-19.Advances in therapy · 2022Review
- Association Between Atopic Dermatitis and Major Cardiovascular Outcomes: a Two-Sample Mendelian Randomization Study.Dermatology practical & conceptual · 2022Review
- Article
- Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study.Journal of atherosclerosis and thrombosis · 2019Article
- Association between eczema and major cardiovascular outcomes in population-based studies: a systematic review protocol.BMJ open · 2017Article
- Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3.Biomolecules & therapeutics · 2017Article
- Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma.Current dermatology reports · 2017Review
- Childhood atopic dermatitis as a precursor for developing attention deficit/hyperactivity disorder.International journal of immunopathology and pharmacologyReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAtopic dermatitis (AD) is an inflammatory skin disorder with a childhood prevalence reaching 20%. An estimated 50% of patients have a life-long chronic course. The purpose of this study was to estimate the risk of first-time myocardial infarction (MI) in patients with AD compared with a general population cohort.
designCohort study.
settingDenmark.
participantsUsing population-based medical registries, we identified individuals born in Denmark from 1947 to 1983 with at least two hospital-diagnoses of AD following inpatient admissions or hospital-based outpatient visits at any age from 1977 to 2013. Individuals with AD were matched with general population controls (10:1) for birth-year and gender. Unique personal identifiers permitted unambiguous data linkage. PRIMARY OUTCOME MEASURES: Follow-up began on the date of AD diagnosis (index date for general population controls) and continued until death, emigration, MI or the year 2013. We computed the 15-year-cumulative incidence of MI following a diagnosis of AD. Comparing patients with AD with the general population cohort, we computed HRs of MI presented with 95% CIs and adjusted for history of diabetes mellitus, hypertension, hyperlipidaemia or stroke, educational level, birth-year and sex.
resultsWe identified 4814 patients diagnosed with AD. The cumulative incidence of MI was 0.6% for patients with AD and 0.4% for their matched controls. The corresponding adjusted HR was 1.74 (1.21 to 2.49). The HR for patients who were not in need of systemic treatment was 1.58 (1.02 to 2.45) and it was 2.40 (1.27 to 4.45) for those who were treated with azathioprine, methotrexate or cyclosporine.
conclusionsHospital-diagnosed AD was associated with increased risk of MI compared with the general population.
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