Evidence map›Paper›PMID 27836728›Full record

ArticleExperimental neurology2017

Altered gene expression profile in a mouse model of SCN8A encephalopathy.

Ryan S Sprissler, Jacy L Wagnon, Rosie K Bunton-Stasyshyn, Miriam H Meisler, Michael F Hammer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
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  8. Reduction ofFrontiers in neuroscience · 2023
    Article
  9. Article
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  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Annals of clinical and translational neurology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan S SprisslerARL Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA.
Jacy L WagnonDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Rosie K Bunton-StasyshynDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Miriam H MeislerDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: meislerm@umich.edu.
Michael F HammerARL Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA; Department of Neurology, University of Arizona, Tucson, AZ 85721, USA. Electronic address: mfh@email.arizona.edu.

Funding

The neuronal sodium channel gene SCN8AR01NS034509 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MIRIAM H MEISLER · 1996 to 2026
$9.5M
NINDS NIH HHS R01 NS034509
6 · The paper itself

Abstract

SCN8A encephalopathy is a severe, early-onset epilepsy disorder resulting from de novo gain-of-function mutations in the voltage-gated sodium channel Na

Indexed as

Brain DiseasesEpilepsyAnimalsDisease Models, AnimalGene Expression RegulationMiceMice, TransgenicMutationNAV1.6 Voltage-Gated Sodium ChannelNeuropeptidesPrincipal Component AnalysisTranscriptomeNAV1.6 Voltage-Gated Sodium ChannelNeuropeptidesScn8a protein, mouseAstrocyteEpileptic encephalopathyGene expressionRNA-seqSeizureSodium channelTranscriptome

Identifiers

PMID27836728
PMCPMC5215827

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.