Evidence map›Paper›PMID 27836675›Full record

ArticleOsteoarthritis and cartilage2017

Association of knee pain with a reduction in thigh muscle strength - a cross-sectional analysis including 4553 osteoarthritis initiative participants.

A Ruhdorfer, W Wirth, F Eckstein

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A RuhdorferInstitute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria. Electronic address: anja.ruhdorfer@pmu.ac.at.
W WirthInstitute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria. Electronic address: wolfgang.wirth@pmu.ac.at.
F EcksteinInstitute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria. Electronic address: felix.eckstein@pmu.ac.at.

Funding

Risk of Incident Knee OA & Clinical Outcomes Based on Imaging BiomarkersR01AR066601 · NIAMS · UNIVERSITY OF ARIZONA · PI GUERMAZI, ALI, KWOH, C KENT · 2014 to 2018
$6.2M
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
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CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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NIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262NIAMS NIH HHS R01 AR066601
6 · The paper itself

Abstract

objectiveTo cross-sectionally determine the quantitative relationship of age-adjusted, sex-specific isometric knee extensor and flexor strength to patient-reported knee pain.

methodsDifference of thigh muscle strength by age, and that of age-adjusted strength per unit increase on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain scale, was estimated from linear regression analysis of 4553 Osteoarthritis Initiative (OAI) participants (58% women). Strata encompassing the minimal clinically important difference (MCID) in knee pain were compared to evaluate a potentially non-linear relationship between WOMAC pain levels and muscle strength.

resultsIn OAI participants without pain, the age-related difference in isometric knee extensor strength was -9.0%/-8.2% (women/men) per decade, and that of flexor strength was -11%/-6.9%. Differences in age-adjusted strength values for each unit of WOMAC pain (1/20) amounted to -1.9%/-1.6% for extensor and -2.5%/-1.7% for flexor strength. Differences in torque/weight for each unit of WOMAC pain ranged from -3.3 to -2.1%. There was no indication of a non-linear relationship between pain and strength across the range of observed WOMAC values, and similar results were observed in women and men.

conclusionEach increase by 1/20 units in WOMAC pain was associated with a ∼2% lower age-adjusted isometric extensor and flexor strength in either sex. As a reduction in muscle strength is known to prospectively increase symptoms in knee osteoarthritis (KOA) and as pain appears to reduce thigh muscle strength, adequate therapy of pain and muscle strength is required in KOA patients to avoid a vicious circle of self-sustaining clinical deterioration.

Indexed as

Age FactorsArthralgiaAustriaCross-Sectional StudiesDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceKnee JointMaleMuscle StrengthOsteoarthritis, KneePain MeasurementQuadriceps MuscleRisk AssessmentKnee osteoarthritisMinimal clinically important differenceThigh muscle strengthWOMAC knee pain score

Identifiers

PMID27836675
PMCPMC5403554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.