Evidence map›Paper›PMID 27836639›Full record

ReviewSeminars in cell & developmental biology2017

Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.

Angelika Doetzlhofer, Karen B Avraham

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Epigenetics in neuronal regeneration.Seminars in cell & developmental biology · 2020
    Review
  11. Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival.Frontiers in cell and developmental biology · 2020
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Angelika DoetzlhoferThe Solomon H. Snyder Department of Neuroscience, the Center for Sensory Biology, the Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. Electronic address: adoetzlhofer@jhmi.edu.
Karen B AvrahamDepartment of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: karena@post.tau.ac.il.
Johns Hopkins Medicine · USTel Aviv University · IL

Funding

Notch Signaling Pathways in Auditory Supporting Cell Differentiation and MaintenanceR01DC011571 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DOETZLHOFER, ANGELIKA · 2011 to 2020
$3.8M
Genomic Approaches to Discovery and Characterization of Genes for Inherited Hearing LossR01DC011835 · NIDCD · TEL AVIV UNIVERSITY · PI AVRAHAM, KAREN B., KANAAN, MOIEN · 2011 to 2022
$3.5M
NIDCD NIH HHS R01 DC011571NIDCD NIH HHS R01 DC011835
6 · The paper itself

Abstract

The vertebrate inner ear houses highly specialized sensory organs, tuned to detect and encode sound, head motion and gravity. Gene expression programs under the control of transcription factors orchestrate the formation and specialization of the non-sensory inner ear labyrinth and its sensory constituents. More recently, epigenetic factors and non-coding RNAs emerged as an additional layer of gene regulation, both in inner ear development and disease. In this review, we provide an overview on how epigenetic modifications and non-coding RNAs, in particular microRNAs (miRNAs), influence gene expression and summarize recent discoveries that highlight their critical role in the proper formation of the inner ear labyrinth and its sensory organs. Finally, we discuss recent insights into how epigenetic factors and miRNAs may facilitate, or in the case of mammals, restrict inner ear sensory hair cell regeneration.

Indexed as

Epigenesis, GeneticAnimalsCell DifferentiationChick EmbryoChromatinGene Expression Regulation, DevelopmentalHair Cells, AuditoryHistonesHomeodomain ProteinsHumansMiceMicroRNAsOrganogenesisOtx Transcription FactorsRegenerationChromatinGbx2 protein, mouseHistonesHomeodomain ProteinsMicroRNAsOtx2 protein, mouseOtx Transcription FactorsDeafnessDNA methylationHair cell regenerationHistone modificationInner ear developmentmicroRNA

Identifiers

PMID27836639
PMCPMC5512292
OpenAlexW2553241892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.