ArticleJournal of biomechanics2016
Transcatheter aortic valves produce unphysiological flows which may contribute to thromboembolic events: An in-vitro study.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Neosinus and Valve Thrombosis After Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2026Pooled it
- Anti-Thrombotic Therapy Following Transcatheter Structural Heart Intervention.Journal of clinical medicine · 2026Review
- Role of Neo-Sinus on Thrombogenicity of Aortic Valve Prostheses: Experimental Proof-of-Concept Study.Cardiovascular engineering and technology · 2025Article
- The Aortic Prosthesis and Aortic Valve Bioprosthesis Trombosis as a Late Complication in Patients after the Bentall Procedure Followed by a Valve-in-Valve Transcatheter Aortic Valve Implantation.Diagnostics (Basel, Switzerland) · 2024Article
- A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis.Annals of biomedical engineering · 2024Article
- Long-term prosthetic-associated subclinical thrombotic events evaluation by cardiac CTA after transcatheter aortic valve implantation: incidence and outcomes.Insights into imaging · 2024Article
- Effect of Sinotubular Junction Size on TAVR Leaflet Thrombosis: A Fluid-Structure Interaction Analysis.Annals of biomedical engineering · 2024Article
- Altered blood flow due to larger aortic diameters in patients with transcatheter heart valve thrombosis.APL bioengineering · 2023Article
- Coronary Obstruction during Valve-in-Valve Transcatheter Aortic Valve Replacement: Pre-Procedural Risk Evaluation, Intra-Procedural Monitoring, and Follow-Up.Journal of cardiovascular development and disease · 2023Review
- The Role of Patient-Specific Morphological Features of the Left Atrial Appendage on the Thromboembolic Risk Under Atrial Fibrillation.Frontiers in cardiovascular medicine · 2022Article
- New adverse coronary events in valve-in-valve TAVR and native TAVR-A 2-year matched cohort.Frontiers in cardiovascular medicine · 2022Article
- Risk factors and clinical effects of subclinical leaflet thrombosis after transcatheter aortic valve replacement.Frontiers in cardiovascular medicine · 2022Article
- Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.Frontiers in bioengineering and biotechnology · 2021Article
- Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation.Royal Society open science · 2020Article
- Predictors and Biomarkers of Subclinical Leaflet Thrombosis after Transcatheter Aortic Valve Implantation.Journal of clinical medicine · 2020Review
- Sinus of Valsalva Thrombosis Detected on Computed Tomography after Transcatheter Aortic Valve Replacement.Korean circulation journal · 2020Article
- Are the dynamic changes of the aortic root determinant for thrombosis or leaflet degeneration after transcatheter aortic valve replacement?Journal of thoracic disease · 2020Review
- New Insights into Valve Hemodynamics.Rambam Maimonides medical journal · 2020Review
- Anticoagulation after Transcatheter Aortic Valve Implantation: Current Status.Interventional cardiology (London, England) · 2020Review
- Three-dimensional extent of flow stagnation in transcatheter heart valves.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTranscatheter aortic valve implantation (TAVI) has been associated with large incidence of ischemic events, whose sources are still unclear. In fact, sub-acute complications cannot be directly related to the severity of the calcification in the host tissues, nor with catheter manipulation during the implant. A potential cause could be local flow perturbations introduced by the implantation approach, resulting in thrombo-embolic consequences. In particular, contrary to the surgical approach, TAVI preserves the presence of the native leaflets, which are expanded in the paravalvular space inside the Valsalva sinuses. The purpose of this study is to verify if this configuration can determine hemodynamic variations which may promote blood cell aggregation and thrombus formation.
methodsThe study was performed in vitro, on idealized models of the patient anatomy before and after TAVI, reproducing a range of physiological operating conditions on a pulse duplicator. The fluid dynamics in the Valsalva sinuses was analyzed and characterized using phase resolved Particle Image Velocimetry.
resultsComparison of the flow downstream the valve clearly indicated major alterations in the fluid mechanics after TAVI, characterized by unphysiological conditions associated with extended stagnation zones at the base of the sinuses.
conclusionThe prolonged stasis observed in the Valsalva sinuses for the configuration modelling the presence of transcatheter aortic valves provides a fluid dynamic environment favourable for red blood cell aggregation and thrombus formation, which may justify some of the recently reported thromboembolic and ischemic events. This suggests the adoption of anticoagulation therapies following TAVI, and some caution in the patients׳ selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.