ReviewSeminars in perinatology2017
Surgical necrotizing enterocolitis.
Review in Seminars in perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 6 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- SARS-CoV-2 infection during pregnancy and necrotizing enterocolitis: case report and review of the literature.Italian journal of pediatrics · 2025Pooled it
- Pooled it
- Factors affecting neurodevelopmental outcome following surgical necrotising enterocolitis: a systematic review.Pediatric surgery international · 2024Pooled it
- Effect of time of diagnosis to surgery on outcome, including long-term neurodevelopmental outcome, in necrotizing enterocolitis.Pediatric surgery international · 2022Pooled it
- Amino acids for the prevention of mortality and morbidity in preterm infants: a systematic review and network meta-analysis.Scientific reports · 2022Pooled it
- Value of abdominal ultrasound in management of necrotizing enterocolitis: a systematic review and meta-analysis.Pediatric surgery international · 2018Pooled it
- Ultrasound-based nomogram for predicting high-risk hepatic portal venous gas in children: a retrospective cohort study.Translational pediatrics · 2026Article
- Article
- An Eight-Parameter Summary of Clinical Findings Associated with Surgical Intervention in Infants with Necrotizing Enterocolitis Without Radiographic Pneumoperitoneum.Children (Basel, Switzerland) · 2026Article
- Surgical treatment for neonates with necrotising enterocolitis in the republic of Ireland: are we just seeing patients at the tip of the iceberg?Irish journal of medical science · 2026Article
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- NINJ1 as a novel biomarker of intestinal injury in necrotizing enterocolitis.BMC pediatrics · 2026Observational
- The bowel loss was preserved with surgical intervention based on multi-item scoring in infants with necrotizing enterocolitis.Frontiers in surgery · 2026Article
- Necrotizing Enterocolitis in Preterm Infants: An Inflammatory Condition at the Crossroads of Intestinal Immaturity, Dysbiosis, and Nutrition.International journal of pediatrics · 2026Review
- Machine Learning-Based Prediction of Surgical Intervention in Preterm Infants with Necrotizing Enterocolitis: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2025Article
- Remote ischemic conditioning in necrotizing enterocolitis: an extended phase I safety study.Pediatric surgery international · 2025Article
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Analysis of risk factors and establishment of a predictive model for brain injury in neonates with surgical necrotizing enterocolitis: a retrospective study.BMC pediatrics · 2025Article
- Predicting surgical NEC in neonates: risk factors and model development.BMC gastroenterology · 2025Article
- The prediction models for the optimal timing of surgical intervention for necrotizing enterocolitis: nomogram vs. five machine learning models.Pediatric surgery international · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although currently available data are variable, it appears that the incidence of surgical necrotizing enterocolitis (NEC) has not decreased significantly over the past decade. Pneumoperitoneum and clinical deterioration despite maximal medical therapy remain the most common indications for operative treatment. Robust studies linking outcomes with specific indications for operation are lacking. Promising biomarkers for severe NEC include fecal calprotectin and S100A12; serum fatty acid-binding protein; and urine biomarkers. Recent advances in ultrasonography make this imaging modality more useful in identifying surgical NEC and near-infrared spectroscopy (NIRS) is being actively studied. Another fairly recent finding is that regionalization of care for infants with NEC likely improves outcomes. The neurodevelopmental outcomes after surgical treatment are known to be poor. A randomized trial near completion will provide robust data regarding neurodevelopmental outcomes after laparotomy versus drainage as the initial operative treatment for severe NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.