Evidence map›Paper›PMID 27836411›Full record

ReviewCurrent opinion in cell biology2017

MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.

Meredith L Weck, Nathan E Grega-Larson, Matthew J Tyska

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Quantifying bristle cell organization inbioRxiv : the preprint server for biology · 2025
    Article
  4. Modulation of Filopodial Myosin Function.bioRxiv : the preprint server for biology · 2025
    Article
  5. The filopodial myosin DdMyo7 is a slow, calcium-regulated motor.The Journal of biological chemistry · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Non-muscle myosin 2 filaments are processive in cells.bioRxiv : the preprint server for biology · 2023
    Article
  13. Myosin motors in sensory hair bundle assembly.Current opinion in cell biology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meredith L WeckDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States.
Nathan E Grega-LarsonDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States.
Matthew J TyskaDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States. Electronic address: matthew.tyska@vanderbilt.edu.

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Training Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4M
Molecular basis of brush border assemblyR01DK095811 · NIDDK · VANDERBILT UNIVERSITY · PI MATTHEW J TYSKA · 2013 to 2026
$4.9M
Role of I-BAR proteins in enterocyte differentiationR01DK111949 · NIDDK · VANDERBILT UNIVERSITY · PI MATTHEW J TYSKA · 2017 to 2026
$4.2M
Regulation of Brush Border Structure by Myosin-1aR01DK075555 · NIDDK · VANDERBILT UNIVERSITY · PI TYSKA, MATTHEW J · 2007 to 2016
$2.7M
Investigating the Role of Myosin 7b in Intra-Microvillar TransportF31DK108528 · NIDDK · VANDERBILT UNIVERSITY · PI WECK, MEREDITH LYNN · 2016 to 2018
$66k
NICHD NIH HHS T32 HD007502NIDDK NIH HHS F31 DK108528NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK075555NIDDK NIH HHS R01 DK095811NIDDK NIH HHS R01 DK111949
6 · The paper itself

Abstract

Unconventional myosins are actin-based molecular motors that serve a multitude of roles within the cell. One group of myosin motors, the MyTH4-FERM myosins, play an integral part in building and maintaining finger-like protrusions, which allow cells to interact with their external environment. Suggested to act primarily as transporters, these motor proteins enrich adhesion molecules, actin-regulatory proteins and other factors at the tips of filopodia, microvilli, and stereocilia. Below we review data from biophysical, biochemical, and cell biological studies, which implicate these myosins as central players in the assembly, maintenance and function of actin-based protrusions.

Indexed as

ActinsAnimalsCell Surface ExtensionsHumansMyosinsPseudopodiaActinsMyosins

Identifiers

PMID27836411
PMCPMC5403704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.