ReviewBMC infectious diseases2016
Mycoplasma pneumoniae-associated mild encephalitis/encephalopathy with a reversible splenial lesion: report of two pediatric cases and a comprehensive literature review.
Review in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Paroxysmal Speech Arrest With Resolving Splenial and Symmetric White Matter Lesions in a Child: A Case Report.Cureus · 2026Article
- Neurological Manifestations ofOpen forum infectious diseases · 2026Article
- Review
- Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Basal Ganglia Involvement in PediatricEpidemiologia (Basel, Switzerland) · 2025Article
- Clinical Variability of Pediatric MERS: Insights from a Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Review
- Japanese Spotted Fever Associated with Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion.Internal medicine (Tokyo, Japan) · 2023Article
- Reversible splenial lesion syndrome in children: a retrospective study of 130 cases.Frontiers in neurology · 2023Article
- Shigella-associated mild encephalitis with reversible splenial lesion in Hospital Center Delafontaine, Saint-Denis, France: a case report.BMC pediatrics · 2022Article
- Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum in childhood: a single-center experience.Turkish journal of medical sciences · 2022Article
- Mild encephalitis/encephalopathy with a reversible splenial lesion associated with systemic Mycoplasma pneumoniae infection in North America: a case report.Journal of medical case reports · 2022Article
- Atypical case of mild encephalopathy/encephalitis with reversible splenial lesion of the corpus callosum (MERS) associated withBMJ case reports · 2021Article
- A cohort study of mild encephalitis/encephalopathy with a reversible splenial lesion in children.Brain and behavior · 2021Article
- Management of pediatric post-infectious neurological syndromes.Italian journal of pediatrics · 2021Article
- Clinically mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated withClinical case reports · 2020Article
- COVID-19 and the central nervous system.Clinical neurology and neurosurgery · 2020Review
- Clinical analysis of reversible splenial lesion syndrome in Chinese adults: A retrospective study of 11 cases.Medicine · 2020Article
- COVID-19-associated mild encephalitis/encephalopathy with a reversible splenial lesion.Journal of the neurological sciences · 2020Article
- Neuro-ophthalmological manifestations as complication of an infection with Mycoplasma pneumoniae and subsequent development of disseminated acute encephalitis.Archivos de la Sociedad Espanola de Oftalmologia · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo literature review exists on Mycoplasma pneumoniae-associated mild encephalitis/encepharopathy with a reversible splenial lesion (MERS).
methodsM.pneumoniae-associated MERS cases were searched till August 2016 using PubMed/Google for English/other-language publications and Ichushi ( http://www.jamas.or.jp/ ) for Japanese-language publications. Inclusion criteria were children fulfilling definition for encephalitis, M.pneumoniae infection, and neuroimaging showing hyperintensity in the splenium of the corpus callosum (SCC) alone (type I) or SCC/other brain areas (type II).
resultsWe described two children with type I and II M.pneumoniae-associated MERS. Thirteen cases found by the search and our 2 cases were reviewed. Mean age, male/female ratio, duration of prodromal illness was 8.3 years, 1.5 and 3.5 days. The most common neurological symptom was drowsiness, followed by abnormal speech/behavior, ataxia, seizure, delirium, confusion, tremor, hallucination, irritability, muscle weakness, and facial nerve paralysis. Fever was the most common non-neurological symptom, followed by cough, headache, gastrointestinal symptoms, headache, lethargy and dizziness. Seizure and respiratory symptoms were less common. All were diagnosed for M.pneumoniae by serology. Cerebrospinal fluid (CSF) M.pneumoniae was undetectable by PCR in the 3 patients. Three patients were clarithromycin-resistant. Leukocytosis, positive C-reactive protein, hyponatremia, CSF pleocytosis and slow wave on electroencephalography frequently occurred. All except 2 were type I MERS. Neuroimaging abnormalities disappeared within 18 days in the majority of patients. All type I patients completely recovered within 19 days. Two type II patients developed neurological sequelae, which recovered 2 and 6 months after onset.
conclusionsPrognosis of M.pneumoniae-associated MERS is excellent. Type II MERS may increase a risk of neurological sequelae.
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