Evidence map›Paper›PMID 27835992›Full record

ArticleBMC biology2016

The evolving world of pseudoenzymes: proteins, prejudice and zombies.

Patrick A Eyers, James M Murphy

Abstract read
In one paragraph

Article in BMC biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Evaluation of the Structure-Function Relationship of SGNH Lipase fromInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Review
  9. Emerging functions of pseudoenzymes.The Biochemical journal · 2023
    Review
  10. Dissecting the structural heterogeneity of proteins by native mass spectrometry.Protein science : a publication of the Protein Society · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Pseudophosphatases as Regulators of MAPK Signaling.International journal of molecular sciences · 2021
    Review
  16. Article
  17. The Roles of Pseudophosphatases in Disease.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patrick A EyersDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. Patrick.eyers@liverpool.ac.uk.
James M MurphyThe Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia. jamesm@wehi.edu.au.

Funding

Biotechnology and Biological Sciences Research Council BB/N021703/1
6 · The paper itself

Abstract

Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs.

Indexed as

EnzymesEvolution, MolecularProteinsSignal TransductionEnzymesProteins

Identifiers

PMID27835992
PMCPMC5106787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.