Evidence map›Paper›PMID 27835970›Full record

ArticleBMC infectious diseases2016

Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection.

JanWillem Duitman, Mercedes Valls Serón, JooYeon Engelen-Lee, Matthijs C Brouwer, C Arnold Spek, Diederik van de Beek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

JanWillem DuitmanCenter for Experimental and Molecular Medicine (CEMM) Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands. j.w.duitman@amc.uva.nl.
Mercedes Valls SerónDepartment of Neurology, Academic Medical Center, 1100DD, Amsterdam, The Netherlands.
JooYeon Engelen-LeeDepartment of Neurology, Academic Medical Center, 1100DD, Amsterdam, The Netherlands.
Matthijs C BrouwerDepartment of Neurology, Academic Medical Center, 1100DD, Amsterdam, The Netherlands.
C Arnold SpekCenter for Experimental and Molecular Medicine (CEMM) Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.
Diederik van de BeekDepartment of Neurology, Academic Medical Center, 1100DD, Amsterdam, The Netherlands.
Academic Medical Center · NLAmsterdam Neuroscience · NLUniversity of Amsterdam · NL

Funding

European Research Council 281156
6 · The paper itself

Abstract

backgroundThe most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus (S.) pneumoniae. CCAAT/enhancer binding protein δ is a transcription factor that has recently been hypothesized to play a detrimental role in outcome of meningitis caused by S. pneumoniae. Here, we studied the role of C/EBPδ prior to the development of pneumococcal meningitis.

methodsWild-type and C/EBPδ-deficient mice (C/EBPδ

resultsS. pneumoniae induces cebpδ expression in the brain during blood-borne brain infection. In comparison to wild-type mice, C/EBPδ

conclusionC/EBPδ facilitates bacterial dissemination to the brain and enhances the immune response in the blood compartment. Our study suggests that C/EBPδ plays a detrimental role during the initial development of blood-borne brain infection.

Indexed as

Streptococcus pneumoniaeAnimalsBacterial LoadBrainCCAAT-Enhancer-Binding Protein-deltaHumansMeningitis, PneumococcalMiceMice, KnockoutTranscription FactorsCCAAT-Enhancer-Binding Protein-deltaTranscription FactorsBlood-borne brain infectionCAAT/enhancer-binding protein δC/EBPδExperimental meningitisStreptococcus pneumoniae

Identifiers

PMID27835970
PMCPMC5106828
OpenAlexW2550735420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.