ArticleVirology journal2016
Detection of a novel circovirus PCV3 in pigs with cardiac and multi-systemic inflammation.
Article in Virology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 230 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
230 citing papers in PubMed, 2 syntheses or guidelines pooled it, 418 citations in OpenAlex.
- Influence of vaccination against infectious diseases on the carbon footprint of fattening pigs: a systematic review.Frontiers in veterinary science · 2024Pooled it
- Virus Metagenomics in Farm Animals: A Systematic Review.Viruses · 2020Pooled it
- Development and Application of a Triplex qPCR Assay for the Simultaneous Detection of African Swine Fever Virus, Porcine Circovirus Type 2, and Porcine Circovirus Type 3.Veterinary sciences · 2026Article
- Isolation and characterization of two porcine circovirus type 2 strains from Heilongjiang Province and Inner Mongolia Autonomous Region.Journal of veterinary science · 2026Article
- First Molecular Detection and Genetic Characterization of Porcine Circovirus 5 in Diagnostic Swine Samples from China.Veterinary sciences · 2026Article
- Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle.Nature communications · 2026Article
- Rodent-borne pathogens as economic and zoonotic health threat to livestock farming: a review.One health (Amsterdam, Netherlands) · 2026Review
- Epidemiological and genetic variation analysis of emerging porcine circovirus type 3 in Henan Province, 2023-2024.BMC veterinary research · 2026Article
- Construction andMicrobiology spectrum · 2026Article
- Epidemiological investigation of PCV2 and PCV3 in three provinces of Northeast China in 2025.BMC veterinary research · 2026Article
- Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.Veterinary pathology · 2026Article
- Detection of PCV3 in various sample types from wild boars in Poland.BMC veterinary research · 2026Article
- Molecular Surveillance and Evolutionary Dynamics of Porcine Circovirus Types 2 and 3 in China, 2022-2025.Transboundary and emerging diseases · 2026Article
- Evidence of Spillover and Recombination Between Domestic Pigs and Wild Boars Provides New Insights into Porcine Circoviruses.Pathogens (Basel, Switzerland) · 2025Article
- Genetic Characterization and Evidence of Capsid Epitope Variation in Porcine Circovirus Type 3 Strains from Vietnamese Swine with Reproductive Disorders.Current microbiology · 2025Article
- Prevalence and genetic analysis of porcine circovirus type 3 (PCV3) in Henan Province of China during 2022-2024.Archives of virology · 2025Article
- Annexin A2 facilitates porcine circovirus type 2 infection by mediating viral attachment to host cells and interacting with the capsid protein.Veterinary research · 2025Article
- Development of a Highly Specific Monoclonal Antibody-Based Sandwich ELISA for Rapid Detection of Porcine Circovirus Type 3.Viruses · 2025Article
- Detection of Porcine Circovirus Type 3 in Free-Ranging Wild Boars and Ticks in Jiangsu Province, China.Viruses · 2025Article
- Advancements in Modern Nucleic Acid-Based Multiplex Testing Methodologies for the Diagnosis of Swine Infectious Diseases.Veterinary sciences · 2025Review
170 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPorcine circovirus 2 causes different clinical syndromes resulting in a significant economic loss in the pork industry. Three pigs with unexplained cardiac and multi-organ inflammation that tested negative for PCV2 and other known porcine pathogens were further analyzed.
methodsHistology was used to identify microscopic lesions in multiple tissues. Metagenomics was used to detect viral sequences in tissue homogenates. In situ hybridization was used to detect viral RNA expression in cardiac tissue.
resultsIn all three cases we characterized the genome of a new circovirus we called PCV3 with a replicase and capsid proteins showing 55 and 35 % identities to the genetically-closest proteins from a bat-feces associated circovirus and were even more distant to those of porcine circovirus 1 and 2. Common microscopic lesions included non-suppurative myocarditis and/or cardiac arteriolitis. Viral mRNA was detected intralesionally in cardiac cells. Deep sequencing in tissues also revealed the presence of porcine astrovirus 4 in all three animals as well as rotavirus A, porcine cytomegalovirus and porcine hemagglutinating encephalomyelitis virus in individual cases.
conclusionThe pathogenicity and molecular epidemiology of this new circovirus, alone or in the context of co-infections, warrants further investigations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.