Evidence map›Paper›PMID 27835913›Full record

ArticleOncotarget2016

Circulation autoantibody against Lamin A/C in patients with Sjögren's syndrome.

Wen Zhang, Chunyan Zhang, Peng Chen, Chunhe Yang, Xianfeng Gan, Muhammad Hussain, Yiping Xun, Yaping Tian, Hongwu Du

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wen Zhang112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Chunyan ZhangDepartment of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, China.
Peng Chen112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Chunhe Yang112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Xianfeng Gan112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Muhammad Hussain112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Yiping Xun112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Yaping TianDepartment of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, China.
Hongwu Du112 Laboratory, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
University of Science and Technology Beijing · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lamin A/C proteins are major components of nuclear laminae and were encoded by the LMNA gene. Recent studies have found that in addition to provides nuclear-membrane strength; it also regulates the gene expression. Lamin A/C has been confirmed as an autoantigen in RA, SLE and vasculitis. Anti-Lamin A/C antibodies also have been found by indirect immunofluorescence method. In this study, we used various research methods to confirm Lamin A/C is an autoantigen in Han Chinese patients with confirmed Sjögren's syndrome (SS). To further investigate the relationship between the autoimmune disease antigens, we compared the amino acid sequence of Lamin A/C epitope and several common antigens' antigenic determinant. As a result, we found that Lamin A/C has similar epitopes with U1RNP. It means that the potential relationship exist between Lamin A/C and U1RNP. Clinical data we collected also showed that anti-Lamin A/C and anti-U1RNP antibodies always appear in same serum sample. Therefore, we speculated that cross-reaction may take place between antigen and potential antigen, which have similar epitope. Then, by epitope spreading, the potential antigen can be a new autoantigen. Our study provided a new thinking for further research about the relationship between autoantigens and their development mechanism in autoimmune diseases.

Indexed as

AdultAgedAutoantibodiesBiomarkersCase-Control StudiesChinaCross ReactionsEnzyme-Linked Immunosorbent AssayEpitopesFemaleHumansLamin Type AMaleMiddle AgedRibonucleoprotein, U1 Small NuclearSjogren's SyndromeAutoantibodiesBiomarkersEpitopesLamin Type ALMNA protein, humanRibonucleoprotein, U1 Small Nuclearautoantigenautoimmune diseasesLamin A/CPathology Sectionsimilar antigen epitopesSjögren’s syndrome

Identifiers

PMID27835913
PMCPMC5348317
OpenAlexW2552332432

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.