ArticlePLoS genetics2016
MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Rapid compensatory evolution within a multiprotein complex preserves telomere integrity.Science (New York, N.Y.) · 2025Article
- Article
- The nanoCUT&RUN technique visualizes telomeric chromatin in Drosophila.PLoS genetics · 2022Article
- The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology.Genetics · 2022Article
- Evolutionary mode for the functional preservation of fast-evolvingOpen biology · 2021Article
- Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.PLoS genetics · 2021Article
- Article
- Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Loss of the RNA trimethylguanosine cap is compatible with nuclear accumulation of spliceosomal snRNAs but not pre-mRNA splicing or snRNA processing during animal development.PLoS genetics · 2020Article
- A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling.Nucleic acids research · 2019Article
- Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance.Current genetics · 2019Review
- Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View.Trends in biochemical sciences · 2018Review
- Nuclear import of Cdc13 limits chromosomal capping.Nucleic acids research · 2018Article
- Mapping Second Chromosome Mutations to Defined Genomic Regions inG3 (Bethesda, Md.) · 2018Article
- Article
- Article
- The Hybrid Incompatibility GenesGenetics · 2017Article
- Article
- Drosophila: Retrotransposons Making up Telomeres.Viruses · 2017Review
- The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.Nucleic acids research · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple complexes protect telomeres. In telomerase-maintained organisms, Shelterin related complexes occupy the duplex region while the CST and Tpp1-Pot1 complexes bind the single stranded overhang of telomeres. Drosophila uses a transposon-based mechanism for end protection. We showed that the HOAP-HipHop complex occupies the duplex region. Whether an ssDNA-binding complex exists is not known. Here we discover a novel protein, Tea, that is specifically enriched at telomeres to prevent telomere fusion. We also identify a complex consisting of Tea and two known capping proteins, Ver and Moi. The Moi-Tea-Ver (MTV) complex purified in vitro binds and protects ssDNA in a sequence-independent manner. Tea recruits Ver and Moi to telomeres, and point mutations disrupting MTV interaction in vitro result in telomere uncapping, consistent with these proteins functioning as a complex in vivo. MTV thus shares functional similarities with CST or TPP1-POT1 in protecting ssDNA, highlighting a conserved feature in end protecting mechanisms.
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