ArticlePloS one2016
QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Influence of poly(A) sequences and genetic elements on iCre expression and induction of a hibernation-like state in mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans.Current biology : CB · 2025Article
- A single injection of neuropeptide QRFP in the lateral hypothalamus decreased food intake.Journal of psychopharmacology (Oxford, England) · 2025Article
- Review
- Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The hypothalamic neuropeptide, QRFP, regulates high fat diet intake in female Long-Evans rats following ovariectomy.Peptides · 2023Article
- Blood Levels of Neuropeptide 26RFa in Relation to Anxiety and Aggressive Behavior in Humans-An Exploratory Study.Brain sciences · 2023Article
- Article
- Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice.Frontiers in neuroscience · 2023Article
- The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.PloS one · 2022Article
- The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.Journal of clinical laboratory analysis · 2021Article
- Heterogeneity of Hypocretin/Orexin Neurons.Frontiers of neurology and neuroscience · 2021Review
- Turn it off and on again: characteristics and control of torpor.Wellcome open research · 2021Review
- Role of the Preoptic Area in Sleep and Thermoregulation.Frontiers in neuroscience · 2021Review
- Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review.Frontiers in neuroscience · 2021Review
- Article
- Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP).BMJ open diabetes research & care · 2020Article
- Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
14 authors.
Funding
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Abstract
How the hypothalamus transmits hunger information to other brain regions to govern whole brain function to orchestrate feeding behavior has remained largely unknown. Our present study suggests the importance of a recently found lateral hypothalamic neuropeptide, QRFP, in this signaling. Qrfp-/- mice were hypophagic and lean, and exhibited increased anxiety-like behavior, and were hypoactive in novel circumstances as compared with wild type littermates. They also showed decreased wakefulness time in the early hours of the dark period. Histological studies suggested that QRFP neurons receive rich innervations from neurons in the arcuate nucleus which is a primary region for sensing the body's metabolic state by detecting levels of leptin, ghrelin and glucose. These observations suggest that QRFP is an important mediator that acts as a downstream mediator of the arcuate nucleus and regulates feeding behavior, mood, wakefulness and activity.
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