Evidence map›Paper›PMID 27835626›Full record

ArticleSexually transmitted diseases2016

Genotype-Specific Concordance of Chlamydia trachomatis Genital Infection Within Heterosexual Partnerships.

Julia A Schillinger, Barry P Katz, Lauri E Markowitz, Phillip G Braslins, Lydia A Shrier, Guillermo Madico, Barbara Van Der Pol, Donald P Orr, Peter A Rice, Byron E Batteiger

Abstract read
In one paragraph

Article in Sexually transmitted diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Association ofFrontiers in cellular and infection microbiology · 2023
    Article
  6. Article
  7. Diagnostics (Basel, Switzerland) · 2022
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Frontiers in microbiology · 2017
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia A SchillingerFrom the *Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA; †Department of Biostatistics, Indiana University School of Medicine and Richard M. Fairbanks School of Public Health, Indianapolis, IN; ‡Section of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, MA; §Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA; ¶Division of Infectious Diseases, Department of Medicine; ∥Section of Adolescent Medicine, and **Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN.
Barry P Katz
Lauri E Markowitz
Phillip G Braslins
Lydia A Shrier
Guillermo Madico
Barbara Van Der Pol
Donald P Orr
Peter A Rice
Byron E Batteiger

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Intramural CDC HHS CC999999NCATS NIH HHS UL1 TR001108
6 · The paper itself

Abstract

backgroundSexual transmission rates of Chlamydia trachomatis (Ct) cannot be measured directly; however, the study of concordance of Ct infection in sexual partnerships (dyads) can help to illuminate factors influencing Ct transmission.

methodsHeterosexual men and women with Ct infection and their sex partners were enrolled and partner-specific coital and behavioral data collected for the prior 30 days. Microbiological data included Ct culture, and nucleic acid amplification testing (NAAT), quantitative Ct polymerase chain reaction, and ompA genotyping. We measured Ct concordance in dyads and factors (correlates) associated with concordance.

resultsOne hundred twenty-one women and 125 men formed 128 dyads. Overall, 72.9% of male partners of NAAT-positive women and 68.6% of female partners of NAAT-positive men were Ct-infected. Concordance was more common in dyads with culture-positive members (78.6% of male partners, 77% of female partners). Partners of women and men who were NAAT-positive only had lower concordance (33.3%, 46.4%, respectively). Women in concordant dyads had significantly higher median endocervical quantitative Ct polymerase chain reaction values (3,032) compared with CT-infected women in discordant dyads (1013 inclusion forming units DNA equivalents per mL; P < 0.01). Among 54 Ct-concordant dyads with ompA genotype data for both members, 96.2% had identical genotypes.

conclusionsHigher organism load appears associated with concordance among women. Same-genotype chlamydial concordance was high in sexual partnerships. No behavioral factors were sufficiently discriminating to guide partner services activities. Findings may help model coitus-specific transmission probabilities.

Indexed as

AdolescentAdultCervix UteriChlamydia InfectionsChlamydia trachomatisCoitusCross-Sectional StudiesFemaleGenital Diseases, FemaleGenital Diseases, MaleGenotypeHeterosexualityHumansMaleNucleic Acid Amplification TechniquesSexual Partners

Identifiers

PMID27835626
PMCPMC5113142

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.