ArticleAIDS (London, England)2017
Depression at antiretroviral therapy initiation and clinical outcomes among a cohort of Tanzanian women living with HIV.
Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Mental health interventions for persons living with HIV in low- and middle-income countries: a systematic review.Journal of the International AIDS Society · 2021Pooled it
- Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: a systematic review and meta-analysis.AIDS (London, England) · 2018Pooled it
- Reducing HIV-Associated Post-Hospital Mortality Through Home-Based Care in South Africa: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Antenatal depression and adverse birth outcomes among pregnant women living with HIV in Dar es Salaam, Tanzania.Journal of affective disorders · 2023Trial
- A peer-facilitated psychological group intervention for perinatal women living with HIV and depression in Tanzania-Healthy Options: A cluster-randomized controlled trial.PLoS medicine · 2022Trial
- The value of hope: development and validation of a contextual measure of hope among people living with HIV in urban Tanzania a mixed methods exploratory sequential study.BMC psychology · 2020Trial
- Depressive symptoms, stigma and suicidal thoughts among people living with HIV/AIDS attending a Tertiary Hospital in Mwanza, Tanzania: A cross-sectional study.PLOS mental health · 2025Article
- Magnitude of Depression and Associated Factors in Women Living With HIV in Northwest, Ethiopia: Mediation Analysis.AIDS research and treatment · 2025Article
- Article
- Mental health burden among females living with HIV and AIDS in sub-Saharan Africa: A systematic review.PLOS global public health · 2024Article
- Effect of a brief psychological intervention for common mental disorders on HIV viral suppression: A non-randomised controlled study of the Friendship Bench in Zimbabwe.PLOS global public health · 2024Article
- Associations Between Social Support and Symptoms of Antenatal Depression with Infant Growth and Development Among Mothers Living with HIV in Tanzania.AIDS and behavior · 2023Article
- Adapting and usability testing of the Kansas city cardiomyopathy questionnaire (KCCQ) in a heart failure clinic in Tanzania: the Swahili KCCQ.BMC cardiovascular disorders · 2023Article
- Prevalence, severity, and associated factors of depression in newly diagnosed people living with HIV in Kilimanjaro, Tanzania: a cross-sectional study.BMC psychiatry · 2023Article
- Article
- Anemia and opportunistic infections in hospitalized people living with HIV: a retrospective study.BMC infectious diseases · 2022Article
- Loneliness as a mediation from social support leading to a decrease of health-related quality of life among PLWHIV.Frontiers in public health · 2022Article
- Depression and Viral Suppression Among Adults Living with HIV in Tanzania.AIDS and behavior · 2021Article
- Improvement in depressive symptoms after antiretroviral therapy initiation in people with HIV in Rakai, Uganda.Journal of neurovirology · 2021Observational
- Common mental disorders and intimate partner violence against pregnant women living with HIV in Cameroon: a cross-sectional analysis.BMC pregnancy and childbirth · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveThe objective of the study was to assess the relationship of depression at antiretroviral therapy (ART) initiation with mortality and clinical outcomes among Tanzanian women living with HIV.
designWe conducted a prospective cohort study of 1487 women who initiated ART in Dar es Salaam, Tanzania.
methodsSymptoms of depression and anxiety were assessed using a Tanzanian-adapted and validated version of the Hopkins Symptom Checklist. Participants attended monthly clinic visits during the first 2 years of ART and CD4 T-cell counts were assessed every 4 months. Proportional hazard models were used to assess the relationship of depression with mortality and clinical outcomes.
resultsSymptoms consistent with depression were prevalent among 57.8% of women at ART initiation. After multivariate adjustment, including social support and stigma, depression at ART initiation was associated with increased risk of mortality [hazard ratio (HR): 1.92; 95% confidence interval (CI): 1.15-3.20; P = 0.01] and incidence of severe anemia (hemoglobin <8.5 g/dl; HR: 1.59; 95% CI: 1.07-2.37; P = 0.02). Under the assumption of causality, we estimate 36.1% (95% CI: 13.6-55.1%) of deaths among the study cohort were attributable to depression and its consequences. Depression was not significantly associated with trajectory of CD4 T-cell reconstitution or the risk of immunologic failure (P values >0.05).
conclusionElimination of depression may reduce mortality during the first 2 years of ART by one-third in our study cohort. Randomized trials and rigorous implementation studies are needed to evaluate the individual and population-level effects of integrated mental health interventions and HIV treatment approaches in resource-limited settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.