Evidence map›Paper›PMID 27835568›Full record

ArticleeLife2016

Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes.

Reza Behrouzi, Chenning Lu, Mark A Currie, Gloria Jih, Nahid Iglesias, Danesh Moazed

Open access · goldAbstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Two-way feedback between chromatin compaction and histone modification state explainsProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Minimal requirements for the epigenetic inheritance of engineered silent chromatin domains.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Nucleosome Positioning Regulates the Establishment, Stability, and Inheritance of Heterochromatin inProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. SIR proteins create compact heterochromatin fibers.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Reza BehrouziDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.ORCID 0000-0003-3064-9743
Chenning LuDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.
Mark A CurrieDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.
Gloria JihDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.
Nahid IglesiasDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.
Danesh MoazedDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.ORCID 0000-0003-0321-6221
Howard Hughes Medical Institute · US

Funding

RNAi-mediated Targeting of Hetorochromatin AssemblyR01GM072805 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MOAZED, DANESH · 2005 to 2025
$6.9M
MECHANISM OF ACTION OF YEAST SILENCING COMPLEXESR01GM061641 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MOAZED, DANESH · 2000 to 2014
$3.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM061641NIGMS NIH HHS R01 GM072805
6 · The paper itself

Abstract

Heterochromatin is a conserved feature of eukaryotic chromosomes with central roles in regulation of gene expression and maintenance of genome stability. Heterochromatin formation involves spreading of chromatin-modifying factors away from initiation points over large DNA domains by poorly understood mechanisms. In

Indexed as

HeterochromatinNucleosomesSaccharomyces cerevisiaeSilent Information Regulator Proteins, Saccharomyces cerevisiaeHeterochromatinNucleosomesSilent Information Regulator Proteins, Saccharomyces cerevisiaeSIR3 protein, S cerevisiaebiochemistrychromatin spreadingchromosomesgenesheterochromatinnucleosomeS. cerevisiaeSir3Sir4

Identifiers

PMID27835568
PMCPMC5106214
OpenAlexW2555083407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.