Evidence map›Paper›PMID 27835525›Full record

ArticleHuman vaccines & immunotherapeutics2017

Assessing the risk of intussusception and rotavirus vaccine safety in Canada.

Steven Hawken, Robin Ducharme, Laura C Rosella, Eric I Benchimol, Joanne M Langley, Kumanan Wilson, Natasha S Crowcroft, Scott A Halperin, Shalina Desai, Monika Naus and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Rotavirus vaccination and intussusception: a paradigm shift?Human vaccines & immunotherapeutics · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Steven Hawkena Ottawa Hospital Research Institute , Clinical Epidemiology Program , Ottawa , Ontario , Canada.
Robin Ducharmea Ottawa Hospital Research Institute , Clinical Epidemiology Program , Ottawa , Ontario , Canada.
Laura C Rosellac Public Health Ontario , Toronto , Ontario , Canada.
Eric I Benchimolb School of Epidemiology, Public Health and Preventive Medicine , University of Ottawa , Ontario , Canada.
Joanne M Langleyf Departments of Pediatrics & Community Health and Epidemiology , Dalhousie University , Halifax , Nova Scotia , Canada.
Kumanan Wilsona Ottawa Hospital Research Institute , Clinical Epidemiology Program , Ottawa , Ontario , Canada.
Natasha S Crowcroftc Public Health Ontario , Toronto , Ontario , Canada.
Scott A Halpering Canadian Centre for Vaccinology , IWK Health Centre , Halifax , Nova Scotia , Canada.
Shalina Desaii Centre for Immunization and Respiratory Infectious Diseases , Public Health Agency of Canada , Ottawa , Ontario , Canada.
Monika Nausj British Columbia Centre for Disease Control, School of Population and Public Health , University of British Columbia , Vancouver , British Columbia , Canada.
Carolyn J Sanfordk Chief Public Health Office , Charlottetown , Prince Edward Island , Canada.
Salah M Mahmudl Vaccine and Drug Evaluation Centre, Community Health Sciences , University of Manitoba , Winnipeg , MB , Canada.
Shelley L Deeksc Public Health Ontario , Toronto , Ontario , Canada.

Funding

CIHR
6 · The paper itself

Abstract

backgroundIntussusception has been identified as a rare adverse event following rotavirus immunization. We sought to determine the incidence of intussusception among infants in Canada both before and after introduction of rotavirus immunization programs.

methodsWe used Canadian Institute for Health Information (CIHI) Discharge Abstract Database (DAD) to identify infants under 1 y of age who were admitted to a Canadian hospital, which the exception of Quebec, which does not submit data to CIHI, with a diagnosis of intussusception (ICD-10 code K56.1, and ICD-9 code 560) between January 1st, 2003 and December 31, 2013. We compared rates of intussusception hospitalization before and after rotavirus vaccine program introduction. Rates were adjusted for calendar year, age (in months), sex and region using Poisson regression models. Denominator data for infants under 1 year, stratified by age in months, were obtained from Statistics Canada.

resultsAnnual intussusception hospitalization rates ranged from 20-30 per 100,000 infants over the study period, with no evidence of a trend over time. Intussusception hospitalization rates were highest in infants 4 to <8 months and lowest in those under 2 months or between 10 and <12 months. Males had higher rates than females both overall and within each age group. The rate of intussusception hospitalization after rotavirus vaccine program introduction was 22.4 (95% CI: 18.3, 27.4) compared to 23.4 (95% CI: 21.5, 25.4) per 100,000 before program introduction.

conclusionsWe have described baseline intussusception hospitalization rates for infants in Canada and have found no evidence of a change in rate after implementation of routine rotavirus immunization programs.

Indexed as

CanadaFemaleHumansIncidenceInfantIntussusceptionMaleRetrospective StudiesRisk AssessmentRotavirus VaccinesRotavirus Vaccinesadverse events following immunizationhealth administrative datahealth services researchintussusceptionpost-marketing surveillanceRotavirus vaccinevaccine safety

Identifiers

PMID27835525
PMCPMC5360150

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.