Clinical outcomes of gamma-irradiated sterile cornea in aqueous drainage device surgery: a multicenter retrospective study.

Q Pan, H D Jampel, P Ramulu, G F Schwartz, F Cotter, D Cute, Y J Daoud, P Murakami, W J Stark

Abstract readMulticenter Study

In one paragraph

Article in Eye (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Comparing the use of Tutopatch® pericardium with Tutoplast® fascia lata in the context of PAUL® glaucoma implant surgery: an anterior segment OCT study.Eye (London, England) · 2025
Article
Unburied polytetrafluoroethylene scleral suture erosions and failure of pericardial graft revision.American journal of ophthalmology case reports · 2024
Article
Management of endophthalmitis related to glaucoma drainage devices: review of the literature and our experience.Eye (London, England) · 2021
Review
Assessing patient cosmetic satisfaction after glaucoma drainage device surgery for different patch grafts.BMC ophthalmology · 2021
Article
A review of long-term corneal preservation techniques: Relevance and renewed interests in the COVID-19 era.Indian journal of ophthalmology · 2020
Review
Electron Beam Irradiated Corneal Versus Gamma-Irradiated Scleral Patch Graft Erosion Rates in Glaucoma Drainage Device Surgery.Ophthalmology and therapy · 2019
Article
Long-term clinical outcomes of keratoplasty using gamma-irradiated corneal lenticules.BMJ open ophthalmology · 2019
Article
Measurement of Gamma-Irradiated Corneal Patch Graft Thickness After Aqueous Drainage Device Surgery.JAMA ophthalmology · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Q PanEye Center, Zhejiang Provincial People's Hospital, Hangzhou, China.

H D JampelWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

P RamuluWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

G F SchwartzGlaucoma Consultants, Baltimore, MD, USA.

F CotterVistar Eye Center, Roanoke, VA, USA.

D CuteWalter Reed National Military Medical Center, Bethesda, MD, USA.

Y J DaoudWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

P MurakamiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

W J StarkWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PurposeThe purpose of the study was to evaluate the safety and efficacy of gamma-irradiated sterile cornea (GISC) for covering the tube in aqueous drainage device (ADD) surgery in a retrospective, multicenter case series.Patients and methodsParticipants included 297 patients (321 procedures) who had undergone ADD surgery for the first time using GISC patch at three clinic centers in the United States between April 2009 and July 2012. The medical records of those consecutive patients were reviewed. Preoperative, intraoperative, and postoperative parameters about GISC were collected and analyzed. The main outcome measures were patch graft failure (PGF) and postoperative complications related to GISC.ResultsThree hundred and nineteen eyes in 295 patients were included in the current analysis. Ten out of the 319 eyes experienced PGF with a mean follow-up of 15.4±9.8 (SD) months. The overall cumulative PGF proportion from Kaplan-Meier analysis was 2.6% (95% CI: 0.6-4.7%) at 18 months. We detected two cases of presumed endophthalmitis related to PGF.ConclusionsGISC appears to have a reasonable success rate for preventing tube exposure related to PGF over an 18-month period. This success rate, in combination with other features of GISC (transparency and storage at room temperature), makes it a viable choice for patch graft material during ADD.

Indexed as

Gamma RaysGlaucoma Drainage ImplantsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCorneaCorneal TransplantationFemaleGlaucomaGraft SurvivalHumansInfantKaplan-Meier Estimate

Identifiers

PMID27834965

DOI10.1038/eye.2016.230

PMCPMC5350361

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.