ArticleProceedings of the National Academy of Sciences of the United States of America1989
Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 96 citations in OpenAlex.
- CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development.PLoS genetics · 2023Article
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- Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas.Cold Spring Harbor perspectives in medicine · 2020Review
- The TCL1 function revisited focusing on metabolic requirements of stemness.Cell cycle (Georgetown, Tex.) · 2019Review
- T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways.Frontiers in oncology · 2018Article
- Mature T-cell leukemias: Molecular and Clinical Aspects.Current hematologic malignancy reports · 2015Review
- Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.Cell cycle (Georgetown, Tex.) · 2014Article
- New strategies in peripheral T-cell lymphoma: understanding tumor biology and developing novel therapies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Review
- ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.The Journal of experimental medicine · 2010Article
- Article
- Article
- Article
- The role of TCL1 in human T-cell leukemia.Oncogene · 2001Review
- The pathogenesis of ataxia-telangiectasia. Learning from a Rosetta Stone.Clinical reviews in allergy & immunology · 2001Review
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia.Oncogene · 2000Article
- Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.Japanese journal of cancer research : Gann · 1998Article
- Solution structure of the recombinant human oncoprotein p13MTCP1.Journal of biomolecular NMR · 1998Article
- Deregulated expression of TCL1 causes T cell leukemia in mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Human T-cell receptor variable gene segment families.Immunogenetics · 1995Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We have detected and cloned two rearrangements in the T-cell receptor alpha locus from a clone of somatic cell hybrids carrying a t(14;14)(q11;q32) chromosomal translocation derived from an ataxia telangiectasia patient with T-cell chronic lymphocytic leukemia. The T-cell clone carrying the t(14;14) chromosomal translocation was known to be present for greater than 10 years before the onset of overt leukemia. One molecular rearrangement of the T-cell receptor alpha locus corresponded to a functional variable-joining region (V-J) joining, whereas the other derived from the breakpoint of the t(14;14)(q11;q32) translocation. Chromosomal in situ hybridization of the probe derived from the t(14;14) breakpoint localized the breakpoint region to 14q32.1, apparently the same region that is involved in another ataxia telangiectasia characteristic chromosome translocation, t(7;14)(q35;q32). The 14q32.1 breakpoint is at least 10,000 kilobase pairs (kbp) centromeric to the immunoglobulin heavy chain locus. Sequence analysis of the breakpoint indicates the involvement of a J alpha sequence during the translocation. Comigration of high-molecular weight DNA fragments involved with t(7;14) and t(14;14) translocations suggests the presence of a cluster of breakpoints in the 14q32.1 region, the site of a putative oncogene, TCL1.
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