Evidence map›Paper›PMID 27834854›Full record

ArticleInternational journal of molecular sciences2016

Pharmacologic Treatment Assigned for Niemann Pick Type C1 Disease Partly Changes Behavioral Traits in Wild-Type Mice.

Victoria Schlegel, Markus Thieme, Carsten Holzmann, Martin Witt, Ulrike Grittner, Arndt Rolfs, Andreas Wree

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Organ Weights inInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Victoria SchlegelInstitute of Anatomy, University of Rostock, 18055 Rostock, Germany. victoria.schlegel@gmx.de.
Markus ThiemeInstitute of Anatomy, University of Rostock, 18055 Rostock, Germany. markus_thieme@gmx.de.
Carsten HolzmannInstitute of Medical Genetics, Rostock University Medical Center, 18057 Rostock, Germany. carsten.holzmann@med.uni-rostock.de.
Martin WittInstitute of Anatomy, University of Rostock, 18055 Rostock, Germany. martin.witt@med.uni-rostock.de.
Ulrike GrittnerDepartment for Biostatistics and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. ulrike.grittner@charite.de.
Arndt RolfsAlbrecht-Kossel Institute for Neuroregeneration, Rostock University Medical Center, 18147 Rostock, Germany. arndt.rolfs@med.uni-rostock.de.
Andreas WreeInstitute of Anatomy, University of Rostock, 18055 Rostock, Germany. andreas.wree@med.uni-rostock.de.
University of Rostock · DECharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick Type C1 (NPC1) is an autosomal recessive inherited disorder characterized by accumulation of cholesterol and glycosphingolipids. Previously, we demonstrated that BALB/c-npc1

Indexed as

1-DeoxynojirimycinAnimalsBehavior, AnimalBody WeightBrainCognitionCyclodextrinsDisease Models, AnimalDrug Administration ScheduleDrug CombinationsHypolipidemic AgentsMaleMaze LearningMiceMice, Inbred BALB CNiemann-Pick Disease, Type C1-DeoxynojirimycinCyclodextrinsDrug CombinationsHypolipidemic AgentsmiglustatPregnanoloneaccelerodallopregnanolonebehaviorcyclodextrinelevated plus mazehot-platemicemiglustatMorris water mazeNPCopen field

Identifiers

PMID27834854
PMCPMC5133866
OpenAlexW2553028855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.