ArticleNutrients2016
Leptin Levels Are Higher in Whole Compared to Skim Human Milk, Supporting a Cellular Contribution.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Relationships between the Intakes of Human Milk Components and Body Composition of Breastfed Infants: A Systematic Review.Nutrients · 2023Pooled it
- The Impact of Gestational Diabetes Mellitus on Human Milk Metabolic Hormones: A Systematic Review.Nutrients · 2022Pooled it
- The Association of Human Milk Appetite-Regulating Hormones with Infant Growth and Eating Behaviors to Age Six Months.Nutrients · 2026Article
- Article
- Human Milk Macronutrients and Bioactive Molecules and Development of Regional Fat Depots in Western Australian Infants during the First 12 Months of Lactation.Life (Basel, Switzerland) · 2022Article
- Review
- Development of Visceral and Subcutaneous-Abdominal Adipose Tissue in Breastfed Infants during First Year of Lactation.Nutrients · 2021Article
- Review
- Human Milk Metabolic Hormones: Analytical Methods and Current Understanding.International journal of molecular sciences · 2021Review
- The Relationship Between Breast Milk Components and the Infant Gut Microbiota.Frontiers in nutrition · 2021Review
- Leptin in Human Milk and Child Body Mass Index: Results of the Ulm Birth Cohort Studies.Nutrients · 2019Article
- Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation.Nutrients · 2018Article
- New Achievements in High-Pressure Processing to Preserve Human Milk Bioactivity.Frontiers in pediatrics · 2018Article
- Associations between Maternal Body Composition and Appetite Hormones and Macronutrients in Human Milk.Nutrients · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human milk (HM) contains a plethora of metabolic hormones, including leptin, which is thought to participate in the regulation of the appetite of the developing infant. Leptin in HM is derived from a combination of de novo mammary synthesis and transfer from the maternal serum. Moreover, leptin is partially lipophilic and is also present in HM cells. However, leptin has predominately been measured in skim HM, which contains neither fat nor cells. We optimised an enzyme-linked immunosorbent assay for leptin measurement in both whole and skim HM and compared leptin levels between both HM preparations collected from 61 lactating mothers. Whole HM leptin ranged from 0.2 to 1.47 ng/mL, whilst skim HM leptin ranged from 0.19 to 0.9 ng/mL. Whole HM contained, on average, 0.24 ± 0.01 ng/mL more leptin than skim HM (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.