Evidence map›Paper›PMID 27834754›Full record

ArticleStroke2016

Impact of Clinical Trial Results on the Temporal Trends of Carotid Endarterectomy and Stenting From 2002 to 2014.

Mohamad A Hussain, Muhammad Mamdani, Jack V Tu, Gustavo Saposnik, Zeyad Khoushhal, Badr Aljabri, Subdoh Verma, Mohammed Al-Omran

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mohamad A HussainFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Muhammad MamdaniFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Jack V TuFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Gustavo SaposnikFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Zeyad KhoushhalFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Badr AljabriFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Subdoh VermaFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.).
Mohammed Al-OmranFrom the Divisions of Vascular Surgery (M.A.H., Z.K., B.A., M.A.-O.), Neurology (G.S.), and Cardiac Surgery (S.V.) and Li Ka Shing Knowledge Institute, St Michael's Hospital (M.M., G.S., S.V., M.A.-O.), Toronto, Canada; Departments of Surgery (M.A.H., S.V., M.A.-O.) and Medicine (J.V.T., G.S.), University of Toronto, Toronto, Canada; Institute of Health Policy, Management, and Evaluation (M.M., J.V.T., G.S.) and Leslie Dan Faculty of Pharmacy (M.M.), University of Toronto, Canada; King Saud University-Li Ka Shing Collaborative Research Program (M.M., B.A., S.V., M.A.-O.); Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia (Z.K.); Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia (B.A., M.A.-O.); Institute for Clinical Evaluative Sciences (M.M., J.V.T., G.S.), Toronto, Canada; and Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Canada (J.V.T.). AlomranM@smh.ca.
Taibah University · SAKing Saud University · SAInstitute for Clinical Evaluative Sciences · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeRandomized trials provide conflicting data for the efficacy of carotid-artery stenting compared with endarterectomy. The purpose of this study was to examine the impact of conflicting clinical trial publications on the utilization rates of carotid revascularization procedures.

methodsWe conducted a population-level time-series analysis of all individuals who underwent carotid endarterectomy and stenting in Ontario, Canada (2002-2014). The primary analysis examined temporal changes in the rates of carotid revascularization procedures after publications of major randomized trials. Secondary analyses examined changes in overall and age, sex, carotid-artery symptom, and operator specialty-specific procedure rates.

resultsA total of 16 772 patients were studied (14 394 endarterectomy [86%]; 2378 stenting [14%]). The overall rate of carotid revascularization decreased from 6.0 procedures per 100 000 individuals ≥40 years old in April 2002 to 4.3 procedures in the first quarter of 2014 (29% decrease; P<0.001). The rate of endarterectomy decreased by 36% (P<0.001), whereas the rate of carotid-artery stenting increased by 72% (P=0.006). We observed a marked increase (P=0.01) in stenting after publication of the SAPPHIRE trial (Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy) in 2004, whereas stenting remained relatively unchanged after subsequent randomized trials published in 2006 (P=0.11) and 2010 (P=0.34). In contrast, endarterectomy decreased after trials published in 2006 (P=0.04) and 2010 (P=0.005).

conclusionsAlthough the overall rates of carotid revascularization and endarterectomy have fallen since 2002, the rate of carotid-artery stenting has risen since the publication of stenting-favorable SAPPHIRE trial. Subsequent conflicting randomized trials were associated with a decreasing rate of carotid endarterectomy.

Indexed as

Randomized Controlled Trials as TopicAgedAged, 80 and overCross-Sectional StudiesEndarterectomy, CarotidEndovascular ProceduresFemaleHumansMaleMiddle AgedOntarioStentscarotid-artery stentingcarotid endarterectomycarotid stenosishealth services researchtrends

Identifiers

PMID27834754
PMCPMC5120767
OpenAlexW2554085032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.