Evidence map›Paper›PMID 27834741›Full record

ArticleStroke2016

Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice.

Yasuo Nishijima, Yosuke Akamatsu, Shih Yen Yang, Chih Cheng Lee, Utku Baran, Shaozhen Song, Ruikang K Wang, Teiji Tominaga, Jialing Liu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Therapeutic Induction of Collateral Flow.Translational stroke research · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. The impact of native leptomeningeal collateralization on rapid blood flow recruitment following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  13. Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  14. Article
  15. The role of carotid stenosis ultrasound scale in the prediction of ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yasuo NishijimaDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Yosuke AkamatsuDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Shih Yen YangDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Chih Cheng LeeDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Utku BaranDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Shaozhen SongDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Ruikang K WangDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Teiji TominagaDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.).
Jialing LiuDepartment of Neurological Surgery, University of California at San Francisco (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); San Francisco Veterans Affairs Medical Center, CA (Y.N., Y.A., S.Y.Y., C.C.L., J.L.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (Y.N., Y.A., T.T.); and Departments of Bioengineering & Ophthalmology, University of Washington, Seattle (U.B., S.S., R.K.W.). jialing.liu@ucsf.edu.
San Francisco VA Medical Center · USTohoku University · JPNeurological Surgery · US

Funding

Neuroplasticity after experimental strokeR01NS071050 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI LIU, JIALING · 2011 to 2015
$1.6M
Mechanisms underlying dampened ischemic tolerance in type 2 diabetesI01BX003335 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI LIU, JIALING · 2016 to 2025
–
Mechanisms underlying Netrin-1-mediated functional recovery after strokeI01RX000655 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI LIU, JIALING · 2012 to 2015
–
BLRD VA I01 BX003335NINDS NIH HHS R01 NS071050RRD VA I01 RX000655
6 · The paper itself

Abstract

background and purposeThe presence of collaterals is associated with a reduced risk of stroke and transient ischemic attack in patients with steno-occlusive carotid artery disease. Although metabolic syndrome negatively impacts collateral status, it is unclear whether and to what extent type 2 diabetes mellitus affects cerebral collateral flow regulation during hypoperfusion.

methodsWe examined the spatial and temporal changes of the leptomeningeal collateral flow and the flow dynamics of the penetrating arterioles in the distal middle cerebral artery and anterior cerebral artery branches over 2 weeks after unilateral common carotid artery occlusion (CCAO) using optical coherent tomography in db/+ and db/db mice. We also assessed the temporal adaptation of the circle of Willis after CCAO by measuring circle of Willis vessel diameters.

resultsAfter unilateral CCAO, db/db mice exhibited diminished leptomeningeal collateral flow compensation compared with db/+ mice, which coincided with a reduced dilation of distal anterior cerebral artery branches, leading to reduced flow not only in pial vessels but also in penetrating arterioles bordering the distal middle cerebral artery and anterior cerebral artery. However, no apparent cell death was detected in either strain of mice during the first week after CCAO. db/db mice also experienced a more severe early reduction in the vessel diameters of several ipsilateral main feeding arteries in the circle of Willis, in addition to a delayed post-CCAO adaptive response by 1 to 2 weeks, compared with db/+ mice.

conclusionsType 2 diabetes mellitus is an additional risk factor for hemodynamic compromise during cerebral hypoperfusion, which may increase the severity and the risk of stroke or transient ischemic attack.

Indexed as

AnimalsArteriolesCerebral AngiographyCerebral Arterial DiseasesCerebrovascular CirculationCircle of WillisCollateral CirculationDiabetes Mellitus, Type 2Disease Models, AnimalMaleMeningesMiceOptical ImagingRisk Factorsanastomosisarteriogenesiscarotid occlusive diseaseCCAOdoppler OCTvascular remodeling

Identifiers

PMID27834741
PMCPMC5134912
OpenAlexW2553470848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.