Evidence map›Paper›PMID 27834679›Full record

ArticleThe Journal of biological chemistry2016

Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).

Stefanie Karlshøj, Roxana Maria Amarandi, Olav Larsen, Viktorija Daugvilaite, Anne Steen, Matjaž Brvar, Aurel Pui, Thomas Michael Frimurer, Trond Ulven, Mette Marie Rosenkilde

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Structure-guided design and engineering of a biparatopic antibody targeting CCR2 in triple negative breast cancer.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  2. Article
  3. "Glyco-sulfo barcodes" regulate chemokine receptor function.Cellular and molecular life sciences : CMLS · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Stefanie KarlshøjFrom the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6505-0883
Roxana Maria AmarandiFrom the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
Olav LarsenFrom the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9054-4690
Viktorija DaugvilaiteFrom the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8786-348X
Anne SteenFrom the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
Matjaž Brvarthe Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Aurel Puithe Faculty of Chemistry, Alexandru Ioan Cuza University of Iaşi, Bd. Carol I No. 11, RO-700506 Iaşi, Romania.
Thomas Michael Frimurerthe Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark, and.
Trond Ulventhe Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Mette Marie RosenkildeFrom the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark, rosenkilde@sund.ku.dk.ORCID http://orcid.org/0000-0001-9600-3254
University of Copenhagen · DKUniversity of Southern Denmark · DKAlexandru Ioan Cuza University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn

Indexed as

Allosteric RegulationAnimalsBinding SitesChelating AgentsChemokine CCL3Chlorocebus aethiopsCOS CellsCrystallography, X-RayHumansModels, MolecularProtein BindingProtein ConformationPyridinesReceptors, CCR5CCL3 protein, humanCCR5 protein, humanChelating AgentsChemokine CCL3pyridinePyridinesReceptors, CCR57-transmembrane helix receptoractivation mechanismallosteric regulationC-C chemokine receptor type 5 (CCR5)computer modelingG protein-coupled receptor (GPCR)small molecule

Identifiers

PMID27834679
PMCPMC5207192
OpenAlexW2556415892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.