ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017
Single passive leg movement-induced hyperemia: a simple vascular function assessment without a chronotropic response.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Passive Mobilization on Vascular Function of Bedridden Oldest Old
Pilot Study on Peripheral Vascular Function in Covid-19 Patient
Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of ischemic conditioning on microvascular reactivity to single passive limb movement in young adults: a pilot study.European journal of applied physiology · 2025Trial
- Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.Physiological reports · 2025Trial
- Improved vascular function and functional capacity following l-citrulline administration in patients with heart failure with preserved ejection fraction: a single-arm, open-label, prospective pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Impaired nitric oxide-dependent endothelial function in young male individuals with obesity before the onset of symptoms and complications.Experimental physiology · 2026Article
- Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025Review
- Vascular dysfunction in COPD with and without chronic respiratory failure: a cross-sectional study.Frontiers in physiology · 2025Article
- Central and peripheral haemodynamics at exercise onset: the role of central command.European journal of applied physiology · 2024Article
- Vascular dysfunction and the age-related decline in critical power.Experimental physiology · 2024Article
- Tracking peripheral vascular function for six months in young adults following SARS-CoV-2 infection.Physiological reports · 2022Article
- Reliability of the passive leg movement assessment of vascular function in men.Experimental physiology · 2022Article
- Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Altered Vascular Endothelium-Dependent Responsiveness in Frail Elderly Patients Recovering from COVID-19 Pneumonia: Preliminary Evidence.Journal of clinical medicine · 2021Article
- Histamine HScience advances · 2021Article
- Article
- The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide.American journal of physiology. Heart and circulatory physiology · 2021Article
- Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2021Article
- Passive leg movement in chronic obstructive pulmonary disease: evidence of locomotor muscle vascular dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Physiological Impact and Clinical Relevance of Passive Exercise/Movement.Sports medicine (Auckland, N.Z.) · 2019Review
- Delineating the age-related attenuation of vascular function: Evidence supporting the efficacy of the single passive leg movement as a screening tool.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Cardiovascular and autonomic responses to passive arm or leg movement in men and women.European journal of applied physiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Passive leg movement (PLM)-induced hyperemia is a novel approach to assess vascular function, with a potential clinical role. However, in some instances, the varying chronotropic response induced by PLM has been proposed to be a potentially confounding factor. Therefore, we simplified and modified the PLM model to require just a single PLM (sPLM), an approach that may evoke a peripheral hemodynamic response, allowing a vascular function assessment, but at the same time minimizing central responses. To both characterize and assess the utility of sPLM, in 12 healthy subjects, we measured heart rate (HR), stroke volume, cardiac output (CO), mean arterial pressure (MAP), leg blood flow (LBF), and calculated leg vascular conductance (LVC) during both standard PLM, consisting of passive knee flexion and extension performed at 1 Hz for 60 s, and sPLM, consisting of only a single passive knee flexion and extension over 1 s. During PLM, MAP transiently decreased (5 ± 1 mmHg), whereas both HR and CO increased from baseline (6.0 ± 1.1 beats/min, and 0.8 ± 0.01 l/min, respectively). Following sPLM, MAP fell similarly (5 ± 2 mmHg; P = 0.8), but neither HR nor CO responses were identifiable. The peak LBF and LVC response was similar for PLM (993 ± 189 ml/min; 11.9 ± 1.5 ml·min NEW & NOTEWORTHY: Using the single passive leg movement (PLM) technique, a variant of the vascular function assessment PLM, we have identified a novel peripheral vascular assessment method that is more easily performed than PLM, which, by not evoking potentially confounding central hemodynamic responses, may be more useful clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.