ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017
Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Effects of Different Intensities and Durations of Aerobic Exercise on Vascular Endothelial Function in Middle-Aged and Elderly People: A Meta-analysis.Frontiers in physiology · 2021Pooled it
- Preworkout dietary nitrate magnifies training-induced benefits to physical function in late postmenopausal women: a randomized pilot study.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- The acute effects of exercise intensity and inorganic nitrate supplementation on vascular health in females after menopause.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Time-Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above-Normal Blood Pressure.Journal of the American Heart Association · 2021Trial
- Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Endothelial function following interval exercise plus low-calorie diet treatment in obese females.Physiological reports · 2019Trial
- Leg vascular function with advancing age in men: the impact of physical activity and endurance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Acute exogenous oestradiol augments endothelial and smooth muscle vasodilatory responsiveness in premenopausal but not postmenopausal females.The Journal of physiology · 2025Article
- Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.Physiological reports · 2025Article
- Sex differences in the impact of controlling nutritional status score on diabetic retinopathy: findings of 2003-2018 National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
- Effects of regular exercise on vascular function with aging: Does sex matter?American journal of physiology. Heart and circulatory physiology · 2024Review
- Training the Vessels: Molecular and Clinical Effects of Exercise on Vascular Health-A Narrative Review.Cells · 2023Review
- Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women.American journal of physiology. Heart and circulatory physiology · 2023Article
- Detrimental Changes in Health during Menopause: The Role of Physical Activity.International journal of sports medicine · 2023Review
- Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging.International journal of molecular sciences · 2022Review
- Translational Potential of High-Resistance Inspiratory Muscle Strength Training.Exercise and sport sciences reviews · 2022Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Promoting healthy cardiovascular aging: emerging topics.The journal of cardiovascular aging · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Aging causes micro- and macrovascular endothelial dysfunction, as assessed by endothelium-dependent dilation (EDD), which can be prevented and reversed by habitual aerobic exercise (AE) in men. However, in estrogen-deficient postmenopausal women, whole forearm microvascular EDD has not been studied, and a beneficial effect of AE on macrovascular EDD has not been consistently shown. We assessed forearm blood flow in response to brachial artery infusions of acetylcholine (FBF NEW & NOTEWORTHY: This is the first study to demonstrate that habitual aerobic exercise may not protect against age/menopause-related whole forearm microvascular endothelial dysfunction in healthy nonobese estrogen-deficient postmenopausal women, consistent with recent findings regarding macrovascular endothelial function. This is in contrast to what is observed in healthy middle-aged and older aerobic exercise-trained men.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.