Evidence map›Paper›PMID 27834615›Full record

ArticleTherapeutic delivery2016

Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents.

Michele Herneisey, Jonathan Williams, Janja Mirtic, Lu Liu, Sneha Potdar, Christina Bagia, Jane E Cavanaugh, Jelena M Janjic

Abstract read
In one paragraph

Article in Therapeutic delivery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele HerneiseyGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Jonathan WilliamsGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Janja MirticFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Lu LiuGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Sneha PotdarGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Christina BagiaGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Jane E CavanaughGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Jelena M JanjicGraduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.

Funding

A Joint Computational/Experimental Biomedical Summer Research Program for UndergrR25DA032519 · NIDA · DUQUESNE UNIVERSITY · PI EVANSECK, JEFFREY D, MADURA, JEFFRY D. · 2011 to 2015
$418k
Multimodal (PET/MR/NIR) imaging supported drug delivery in inflammatory diseasesR21EB023104 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANDERSON, CAROLYN J., JANJIC, JELENA M · 2016 to 2017
$409k
Novel small molecule inhibitors of MEK5_ERK5 for the treatment of breast cancerR15CA176496 · NCI · DUQUESNE UNIVERSITY · PI CAVANAUGH, JANE E · 2014 to 2014
$394k
Theranostic Pain Nanomedicines: imaging inflammation, reducing pain and need for opioidsR21DA039621 · NIDA · DUQUESNE UNIVERSITY · PI JANJIC, JELENA M · 2015 to 2016
$328k
NCI NIH HHS R15 CA176496NIBIB NIH HHS R21 EB023104NIDA NIH HHS R21 DA039621NIDA NIH HHS R25 DA032519
6 · The paper itself

Abstract

aimDelivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release.

conclusionPFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases. [Formula: see text].

Indexed as

Molecular ImagingStilbenesBiological AvailabilityEmulsionsResveratrolTissue DistributionEmulsionsResveratrolStilbenesmacrophagenanoemulsionperfluorocarbonperfluoropolyetherresveratroltheranostic

Identifiers

PMID27834615
PMCPMC5239992

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.