Evidence map›Paper›PMID 27834316›Full record

ArticleAsian journal of andrology

Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men.

Lidia MInguez-Alarcón, Jorge E Chavarro, Jaime Mendiola, Manuela Roca, Cigdem Tanrikut, Jesús Vioque, Niels Jørgensen, Alberto M Torres-Cantero

Open access · goldAbstract read
In one paragraph

Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Exposure to Dim Light at Night Impairs Photoperiodic and Metabolic Gene Expression in Syrian Hamsters (Mesocricetus auratus).Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Lidia MInguez-AlarcónDepartment of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
Jorge E ChavarroDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Jaime MendiolaDepartment of Health and Social Sciences, Division of Preventive Medicine and Public Health, University of Murcia School of Medicine, IMIB-Arrixaca, Espinardo (Murcia), Spain.
Manuela RocaRoca Fertility, Advanced Clinic Management SLU, Murcia, Spain.
Cigdem TanrikutDepartment of Urology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jesús VioqueCIBER Epidemiology and Public Health (CIBERESP), Institute of Health III (ISCIII), Madrid, Spain.
Niels JørgensenDepartment of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Alberto M Torres-CanteroDepartment of Health and Social Sciences, Division of Preventive Medicine and Public Health, University of Murcia School of Medicine, IMIB-Arrixaca, Espinardo (Murcia), Spain.
Universidad de Murcia · ESCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESHarvard University · USIVI Murcia Clinic · ESMassachusetts General Hospital · USRigshospitalet · DK

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
NIDDK NIH HHS P30 DK046200
6 · The paper itself

Abstract

Emerging evidence suggests that dietary fats may influence testicular function. However, most of the published literature on this field has used semen quality parameters as the only proxy for testicular function. We examined the association of fat intake with circulating reproductive hormone levels and testicular volume among healthy young Spanish men. This is a cross-sectional study among 209 healthy male volunteers conducted between October 2010 and November 2011 in Murcia Region of Spain. Participants completed questionnaires on lifestyle, diet, and smoking, and each underwent a physical examination, and provided a blood sample. Linear regression was used to examine the association between each fatty acid type and reproductive hormone levels and testicular volumes. Monounsaturated fatty acids intake was inversely associated with serum blood levels of calculated free testosterone, total testosterone, and inhibin B. A positive association was observed between the intake of polyunsaturated fatty acids, particularly of omega-6 polyunsaturated fatty acids, and luteinizing hormone concentrations. In addition, the intake of trans fatty acids was associated with lower total testosterone and calculated free testosterone concentrations (P trend = 0.01 and 0.02, respectively). The intake of omega-3 polyunsaturated fatty acids was positively related to testicular volume while the intake of omega-6 polyunsaturated fatty acids and trans fatty acids was inversely related to testicular volume. These data suggest that fat intake, and particularly intake of omega 3, omega 6, and trans fatty acids, may influence testicular function.

Indexed as

Dietary FatsFatty Acids, Omega-3Fatty Acids, Omega-6Trans Fatty AcidsCross-Sectional StudiesEstradiolFatty Acids, UnsaturatedFollicle Stimulating HormoneHealthy VolunteersHumansInhibinsLinear ModelsLuteinizing HormoneMaleOrgan SizeSemen AnalysisDietary FatsEstradiolFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedFollicle Stimulating Hormoneinhibin BInhibinsLuteinizing HormoneSex Hormone-Binding GlobulinTestosteroneTrans Fatty Acids

Identifiers

PMID27834316
PMCPMC5312216
OpenAlexW2556937679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.