Evidence map›Paper›PMID 27834315›Full record

ArticleNanotechnology2016

AFM study shows prominent physical changes in elasticity and pericellular layer in human acute leukemic cells due to inadequate cell-cell communication.

Nataliia V Guz, Sapan J Patel, Maxim E Dokukin, Bayard Clarkson, Igor Sokolov

Abstract read
In one paragraph

Article in Nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nataliia V GuzDepartment of Chemistry, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5820, USA.
Sapan J PatelDepartment of Chemistry, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5820, USA.
Maxim E DokukinDepartment of Mechanical Engineering, Tufts University, 200 Boston Ave, Medford, MA, USA.
Bayard ClarksonMemorial Sloan Kettering Cancer Center, Sloan Kettering Institute, Molecular Pharmacology and Chemistry Program, 415 East 68th Street, New York, NY 10065, USA.
Igor SokolovDepartment of Mechanical Engineering, Tufts University, 200 Boston Ave, Medford, MA, USA.
Memorial Sloan Kettering Cancer Center · USTufts University · USClarkson University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Biomechanical properties of single cells in vitro or ex vivo and their pericellular interfaces have recently attracted a lot of attention as a potential biophysical (and possibly prognostic) marker of various diseases and cell abnormalities. At the same time, the influence of the cell environment on the biomechanical properties of cells is not well studied. Here we use atomic force microscopy to demonstrate that cell-cell communication can have a profound effect on both cell elasticity and its pericellular coat. A human pre-B p190

Indexed as

Cell CommunicationCell LineElasticityElastic ModulusHumansMicroscopy, Atomic Force

Identifiers

PMID27834315
PMCPMC5221648
OpenAlexW2554014482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.