Postoperative changes in high mobility group box 1 levels after colorectal cancer surgery.

Masaaki Satoh, Kazuhiko Kotani, Shingo Yamada, Koji Koinuma, Hisanaga Horie, Mamoru Takeuchi

Open access · goldAbstract read

In one paragraph

Article in The Journal of international medical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study.BMC anesthesiology · 2020
Observational

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Masaaki Satoh1 Department of Anaesthesiology and Critical Care Medicine, Jichi Medical University, Tochigi, Japan.

Kazuhiko Kotani2 Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan.

Shingo Yamada3 Central Laboratory, Shino-Test Corporation, Kanagawa, Japan.

Koji Koinuma4 Department of Surgery, Jichi Medical University, Tochigi, Japan.

Hisanaga Horie4 Department of Surgery, Jichi Medical University, Tochigi, Japan.

Mamoru Takeuchi1 Department of Anaesthesiology and Critical Care Medicine, Jichi Medical University, Tochigi, Japan.

Jichi Medical University · JPShino-Test Corporation

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective To investigate the potential use of high mobility group box 1 (HMGB1) as a marker for the surgical course following surgery for colorectal cancer (CRC). Methods Patients with advanced CRC undergoing open colorectal surgery who did not develop postsurgical complications were enrolled in the study. Blood samples were taken preoperatively and at 1 day, 1 week and 3 weeks after surgery for the measurement of the white blood cell count, serum C-reactive protein, serum amyloid A and HMGB1. Results Data from 21 patients were analysed. HMGB1 levels changed significantly during the surgical course, increasing from a preoperative median of 6.8 ng/ml to 12.1 ng/ml at 1 day postoperatively, and then decreasing to 8.1 ng/ml at 1 week postoperatively and 4.0 ng/ml at 3 weeks postoperatively. These changes were similar to but were not completely correlated with the changes seen in the other markers. Conclusion Serum HMGB1 may be a potential marker to monitor the surgical course in patients undergoing surgery for CRC, although further studies are warranted before it can be introduced into routine clinical practice.

Indexed as

Colorectal SurgeryPostoperative CareAgedBiomarkers, TumorColorectal NeoplasmsFemaleHMGB1 ProteinHumansMaleBiomarkers, TumorHMGB1 ProteinCancercolorectal surgeryC-reactive proteinhigh mobility group box 1serum amyloid Awhite blood cell count

Identifiers

PMID27834305

DOI10.1177/0300060516665455

PMCPMC5805184

OpenAlexW2551746620

What OpenQuestion holds

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LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.