Evidence map›Paper›PMID 27834284›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal

Jatta S Takkinen, Francisco R López-Picón, Rana Al Majidi, Olli Eskola, Anna Krzyczmonik, Thomas Keller, Eliisa Löyttyniemi, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Assessment of early-phase [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Positron Emission Tomography with [International journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. [Annals of nuclear medicine · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. [EJNMMI research · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Direct Comparison of [Molecular imaging and biology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jatta S Takkinen1 MediCity Research Laboratory, University of Turku, Turku, Finland.
Francisco R López-Picón1 MediCity Research Laboratory, University of Turku, Turku, Finland.
Rana Al Majidi1 MediCity Research Laboratory, University of Turku, Turku, Finland.
Olli Eskola2 Turku PET Centre, University of Turku, Turku, Finland.
Anna Krzyczmonik2 Turku PET Centre, University of Turku, Turku, Finland.
Thomas Keller2 Turku PET Centre, University of Turku, Turku, Finland.
Eliisa Löyttyniemi3 The Department of Biostatistics, University of Turku, Turku, Finland.
Olof Solin2 Turku PET Centre, University of Turku, Turku, Finland.
Juha O Rinne6 Turku PET Centre, Turku University Hospital, Turku, Finland.
Merja Haaparanta-Solin1 MediCity Research Laboratory, University of Turku, Turku, Finland.
University of Turku · FITurku PET Centre · FIÅbo Akademi University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical animal model studies of brain energy metabolism and neuroinflammation in Alzheimer's disease have produced conflicting results, hampering both the elucidation of the underlying disease mechanism and the development of effective Alzheimer's disease therapies. Here, we aimed to quantify the relationship between brain energy metabolism and neuroinflammation in the APP/PS1-21 transgenic mouse model of Alzheimer's disease using longitudinal in vivo

Indexed as

Alzheimer DiseaseBrainEncephalitisEnergy MetabolismAgingAmyloid beta-Protein PrecursorAnimalsAutoradiographyGlucose-6-PhosphateMice, TransgenicPositron-Emission TomographyPresenilin-1PyrazolesPyrimidines2-fluoro-2-deoxyglucose-6-phosphateAmyloid beta-Protein PrecursorGlucose-6-PhosphateN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePresenilin-1PyrazolesPyrimidines18F-DPA-71418F-FDGAlzheimer’s diseaselongitudinal imagingPET

Identifiers

PMID27834284
PMCPMC5536795
OpenAlexW2549490271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.