Evidence map›Paper›PMID 27834283›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness.

Gülin Öz, Mauro DiNuzzo, Anjali Kumar, Amir Moheet, Ameer Khowaja, Kristine Kubisiak, Lynn E Eberly, Elizabeth R Seaquist

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Gülin Öz1 Department of Radiology, University of Minnesota, Minneapolis, USA.
Mauro DiNuzzo2 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anjali Kumar3 Department of Medicine, University of Minnesota, Minneapolis, USA.
Amir Moheet3 Department of Medicine, University of Minnesota, Minneapolis, USA.
Ameer Khowaja3 Department of Medicine, University of Minnesota, Minneapolis, USA.
Kristine Kubisiak4 Division of Biostatistics, University of Minnesota, Minneapolis, USA.
Lynn E Eberly4 Division of Biostatistics, University of Minnesota, Minneapolis, USA.
Elizabeth R Seaquist3 Department of Medicine, University of Minnesota, Minneapolis, USA.
University of Minnesota · USUniversity of Copenhagen · DK

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114
6 · The paper itself

Abstract

Supercompensated brain glycogen levels may contribute to the development of hypoglycemia-associated autonomic failure (HAAF) following recurrent hypoglycemia (RH) by providing energy for the brain during subsequent periods of hypoglycemia. To assess the role of glycogen supercompensation in the generation of HAAF, we estimated the level of brain glycogen following RH and acute hypoglycemia (AH). After undergoing 3 hyperinsulinemic, euglycemic and 3 hyperinsulinemic, hypoglycemic clamps (RH) on separate occasions at least 1 month apart, five healthy volunteers received [1-

Indexed as

Adaptation, PhysiologicalAdultBlood GlucoseBrainCarbon IsotopesGlycogenHealthy VolunteersHumansHypoglycemiaMagnetic Resonance SpectroscopyMaleModels, BiologicalRecurrenceBlood GlucoseCarbon IsotopesGlycogen13C magnetic resonance spectroscopybiophysical modelingglycogenhypoglycemia-associated autonomic failuresupercompensation

Identifiers

PMID27834283
PMCPMC5536796
OpenAlexW2553624540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.