ArticleWorld journal of surgery2017
Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?
Article in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Feasibility of Hyperfunctioning Parathyroid Gland Localization Using [Molecular imaging and biology · 2019Trial
- Trial
- Molecular Imaging in Parathyroid Carcinoma Management: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Diagnostic Ability and Correlation of DigitalNuclear medicine and molecular imaging · 2025Article
- Preoperative localization of water clear cell giant parathyroid adenoma: A case report.Radiology case reports · 2024Article
- Primary hyperparathyroidism: predictors of sporadic multi-gland disease.Endocrine connections · 2024Review
- Head-to-Head Comparison of Tc-99m-sestamibi SPECT/CT and C-11-L-Methionin PET/CT in Parathyroid Scanning Before Operation for Primary Hyperparathyroidism.Molecular imaging and biology · 2023Article
- Article
- The EANM practice guidelines for parathyroid imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Next-Generation Molecular Imaging of Thyroid Cancer.Cancers · 2021Review
- A retrospective analysis of the diagnostic performance ofEJNMMI research · 2021Article
- Parathyroid carcinoma in a 13-year-old girl with a long-term survival.Surgical case reports · 2020Article
- The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Observational
- Can Met-PET/CT Predict Sporadic Multiglandular Hyperparathyroidism? Report of a Case and Review of the Literature.Case reports in endocrinology · 2019Article
- Follicular thyroid cancer avid on C-11 Methionine PET/CT.Endocrinology, diabetes & metabolism case reports · 2018Article
- [Diagnostics and treatment of primary hyperparathyroidism].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc-99 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) is able to localise sestamibi-negative hyperfunctioning parathyroid glands.
methodsIn 50 patients (38 females, 12 males, age 13-81 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met-PET/CT was performed before parathyroid surgery. The results of Met-PET/CT were analysed prospectively and compared with intraoperative and histopathological findings. 22% of the patients underwent previous parathyroid and/or thyroid surgery.
resultsMet-PET/CT correctly located a single-gland adenoma in 33 of 45 (73%) patients with pHPT. In 5 patients with multiglandular disease, Met-PET/CT detected at least one hyperfunctional parathyroid gland in 4 patients (80%). In 3 patients with double adenomas, 5 of 6 parathyroids were correctly located. Overall, 40 of 57 (70%) hyperfunctioning glands were identified with Met-PET/CT. Met-PET/CT was false-negative in 12 of 50 (24%) patients and false-positive in only one case (2%). Postoperatively, 48 of 50 patients (96%) were cured.
conclusionsAdditional pre-interventional imaging with Met-PET/CT was able to identify hyperfunctioning parathyroid glands in 74% of patients with pHPT and negative sestamibi scans, thus enabling successful parathyroid surgery.
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