Evidence map›Paper›PMID 27834005›Full record

ArticleJournal of cancer research and clinical oncology2017

FIGO stage IIIC endometrial cancer identification among patients with complex atypical hyperplasia, grade 1 and 2 endometrioid endometrial cancer: laparoscopic indocyanine green sentinel lymph node mapping versus frozen section of the uterus, why get around the problem?

Andrea Papadia, Maria Luisa Gasparri, Franziska Siegenthaler, Sara Imboden, Stefan Mohr, Michael D Mueller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.Virchows Archiv : an international journal of pathology · 2021
    Guideline
  2. Review
  3. Article
  4. Article
  5. Surgical staging in endometrial cancer.Journal of cancer research and clinical oncology · 2019
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Andrea PapadiaDepartment of Obstetrics and Gynecology, University Hospital of Berne, University of Berne, Effingerstrasse 102, 3010, Bern, Switzerland. andrea.papadia@insel.ch.ORCID http://orcid.org/0000-0002-4909-9588
Maria Luisa GasparriDepartment of Obstetrics and Gynecology, University Hospital of Berne, University of Berne, Effingerstrasse 102, 3010, Bern, Switzerland.
Franziska SiegenthalerDepartment of Obstetrics and Gynecology, University Hospital of Berne, University of Berne, Effingerstrasse 102, 3010, Bern, Switzerland.
Sara ImbodenDepartment of Obstetrics and Gynecology, University Hospital of Berne, University of Berne, Effingerstrasse 102, 3010, Bern, Switzerland.
Stefan MohrDepartment of Obstetrics and Gynecology, University Hospital of Berne, University of Berne, Effingerstrasse 102, 3010, Bern, Switzerland.
Michael D MuellerDepartment of Obstetrics and Gynecology, University Hospital of Berne, University of Berne, Effingerstrasse 102, 3010, Bern, Switzerland.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare two surgical strategies used to identify lymph node metastases in patients with preoperative diagnosis of complex atypical hyperplasia (CAH), grade 1 and 2 endometrial cancer (EC).

methodsData on patients with preoperative diagnosis of CAH, grade 1 and 2 EC undergoing laparoscopic indocyanine green (ICG) sentinel lymph node (SLN) mapping followed by frozen section of the uterus were collected. When risk factors were identified at frozen section, patients were subjected to a systematic lymphadenectomy. False negative (FN) rates, negative predictive values (NPV), positive predictive values (PPV) and correlation with stage IIIC EC were calculated for the systematic lymphadenectomy based on frozen section of the uterus and for the SLN mapping.

resultsSix (9.5%) out of 63 patients had lymph nodal metastases. Based on frozen section of the uterus, 22 (34.9%) and 15 (22.2%) patients underwent a pelvic and a pelvic and paraaortic lymphadenectomy, respectively. Five patients with stage IIIC disease were identified with a FN rate of 16.7% and a NPV and PPV of 97.6 and 27.3%, respectively. Overall and bilateral detection rates of ICG SLN mapping were 100 and 97.6%, respectively; no FN were recorded. The identification of patients with stage IIIC disease with ICG SLN mapping showed a NPV and PPV of 100%. Correlation between indication to lymphadenectomy and stage IIIC disease was poor (κ = 0.244) when based on frozen section of the uterus and excellent (κ = 1) when based on SLN mapping.

conclusionsICG SLN mapping reduces the number of unnecessary systematic lymphadenectomies and the risk of underdiagnosing patients with metastatic lymph nodes.

Indexed as

AdultAgedEndometrial NeoplasmsFemaleFrozen SectionsHumansIndocyanine GreenLymphatic MetastasisLymph Node ExcisionLymph NodesMiddle AgedNeoplasm GradingNeoplasm StagingUterusIndocyanine GreenEndometrial cancerFrozen sectionIndocyanine greenLaparoscopySentinel lymph node mappingSurgical staging

Identifiers

PMID27834005
PMCPMC11819402
OpenAlexW2550043086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.