Evidence map›Paper›PMID 27833819›Full record

ArticlePeerJ2016

Salivary microbiomes of indigenous Tsimane mothers and infants are distinct despite frequent premastication.

Cliff S Han, Melanie Ann Martin, Armand E K Dichosa, Ashlynn R Daughton, Seth Frietze, Hillard Kaplan, Michael D Gurven, Joe Alcock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Pre-chewing for weaning: A traditional method for allergy prevention? Rationale, study design, and methods of the open-label trial-Solids-by-Kiss.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  4. Article
  5. Article
  6. Observational
  7. Olfaction scaffolds the developing human from neonate to adolescent and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
  8. Cigarette Smoking Modulation of Saliva Microbial Composition and Cytokine Levels.International journal of environmental research and public health · 2018
    Article
  9. Role of priority effects in the early-life assembly of the gut microbiota.Nature reviews. Gastroenterology & hepatology · 2018
    Review
  10. Article
  11. Journal of oral microbiology · 2017
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Cliff S Han *Bioscience Division, Los Alamos National LaborataoryLos Alamos, NM, USA.
Melanie Ann Martin *Department of Anthropology, Yale University, New Haven, CA, USA.
Armand E K DichosaBioscience Division, Los Alamos National LaborataoryLos Alamos, NM, USA.
Ashlynn R DaughtonAnalytics, Intelligence and Technology (A) Division, Los Alamos National Laborataory, Los Alamos, NM, USA.
Seth FrietzeDepartment of Medical Laboratory and Radiation Sciences, University of Vermont, Burlington, VT, USA.
Hillard KaplanDepartment of Anthropology, University of New Mexico, Albuquerque, NM, USA.
Michael D GurvenDepartment of Anthropology, University of California, Santa BarbaraSanta Barbara, CA, USA.
Joe AlcockDepartment of Emergency Medicine, University of New Mexico, Albuquerque, NM, USA.
Los Alamos National Laboratory · USUniversity of New Mexico · USUniversity of California, Santa Barbara · USUniversity of Vermont Medical Center · USYale University · US

Funding

The Human Life Course and the Biodemography of AgingR01AG024119 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GURVEN, MICHAEL DOUGLAS, KAPLAN, HILLARD S · 2004 to 2015
$7.4M
The Human Life Course and the Biodemography of AgingR56AG024119 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GURVEN, MICHAEL DOUGLAS, KAPLAN, HILLARD S · 2009 to 2015
$1.0M
NIA NIH HHS R01 AG024119NIA NIH HHS R56 AG024119
6 · The paper itself

Abstract

backgroundPremastication, the transfer of pre-chewed food, is a common infant and young child feeding practice among the Tsimane, forager-horticulturalists living in the Bolivian Amazon. Research conducted primarily with Western populations has shown that infants harbor distinct oral microbiota from their mothers. Premastication, which is less common in these populations, may influence the colonization and maturation of infant oral microbiota, including via transmission of oral pathogens. We collected premasticated food and saliva samples from Tsimane mothers and infants (9-24 months of age) to test for evidence of bacterial transmission in premasticated foods and overlap in maternal and infant salivary microbiota. We extracted bacterial DNA from two premasticated food samples and 12 matched salivary samples from maternal-infant pairs. DNA sequencing was performed with MiSeq (Illumina). We evaluated maternal and infant microbial composition in terms of relative abundance of specific taxa, alpha and beta diversity, and dissimilarity distances.

resultsThe bacteria in saliva and premasticated food were mapped to 19 phyla and 400 genera and were dominated by Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes. The oral microbial communities of Tsimane mothers and infants who frequently share premasticated food were well-separated in a non-metric multi-dimensional scaling ordination (NMDS) plot. Infant microbiotas clustered together, with weighted Unifrac distances significantly differing between mothers and infants. Infant saliva contained more Firmicutes (

conclusionsSalivary microbiota of Tsimane infants and young children up to two years of age do not appear closely related to those of their mothers, despite frequent premastication and preliminary evidence that maternal bacteria is transmitted to premasticated foods. Infant physiology and diet may constrain colonization by maternal bacteria, including several oral pathogens.

Indexed as

GingivitisInfant microbial developmentKinshipMicrobe sharingMicrobial diversityOral diseaseOral microbiotaPremasticationVertical transmission

Identifiers

PMID27833819
PMCPMC5101600
OpenAlexW2549012238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.