ArticleClinical psychological science : a journal of the Association for Psychological Science2016
Striatal Dopamine, Externalizing Proneness, and Substance Abuse: Effects on Wanting and Learning during Reward-Based Decision Making.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Acute stress improves long-term reward maximization in decision-making under uncertainty.Brain and cognition · 2019Trial
- A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [Alcohol, clinical & experimental research · 2025Article
- Effects of individual and dyadic decision-making and normative reference on delay discounting decisions.Cognitive research: principles and implications · 2022Article
- The Effect of Mindfulness Meditation on Impulsivity and its Neurobiological Correlates in Healthy Adults.Scientific reports · 2019Article
- Substance use is associated with reduced devaluation sensitivity.Cognitive, affective & behavioral neuroscience · 2019Review
- Examining the link between reward and response inhibition in individuals with substance abuse tendencies.Drug and alcohol dependence · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We examined whether striatal dopamine moderates the impact of externalizing proneness (disinhibition) on reward-based decision-making. Participants completed disinhibition and substance abuse subscales of the brief form Externalizing Spectrum Inventory, and then performed a delay discounting task to assess preference for immediate rewards along with a dynamic decision-making task that assessed long-term reward learning (i.e., inclination to choose larger delayed versus smaller immediate rewards). Striatal tonic dopamine levels were operationalized using spontaneous eyeblink rate. Regression analyses revealed that high disinhibition predicted greater delay discounting among participants with lower levels of striatal dopamine only, while substance abuse was associated with poorer long-term learning among individuals with lower levels of striatal dopamine, but better long-term learning in those with higher levels of striatal dopamine. These results suggest that disinhibition is more strongly associated with the
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.