ArticleNeuro-oncology practice2016
A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis
Open access · bronzeAbstract read
In one paragraph
Article in Neuro-oncology practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Bevacizumab vs laser interstitial thermal therapy in cerebral radiation necrosis from brain metastases: a systematic review and meta-analysis.Journal of neuro-oncology · 2021Pooled it
- Radiological diagnosis of brain radiation necrosis after cranial irradiation for brain tumor: a systematic review.Radiation oncology (London, England) · 2019Pooled it
- Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.The Cochrane database of systematic reviews · 2018Pooled it
- Focal radiation necrosis of the brain in patients with melanoma brain metastases treated with pembrolizumab.Cancer medicine · 2018Trial
- Efficacy of Docetaxel Plus Ramucirumab for Malignant Pleural Effusion and Cerebral Edema in Patients With Advanced Non-Small Cell Lung Cancer: A Single-Institution Retrospective Study.Thoracic cancer · 2026Article
- Radiation Necrosis in Neuro-Oncology: Diagnostic Complexity and Precision Radiotherapy Strategies.Cancers · 2025Review
- Bevacizumab for symptomatic cerebral radiation necrosis after radiation of high-grade glioma or brain metastases - when and for whom?Neuro-oncology practice · 2025Review
- The role of FET-PET in patient selection and response assessment for reirradiation in recurrent glioblastoma.Frontiers in oncology · 2025Review
- Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy.Current treatment options in oncology · 2023Review
- Korean Brain Tumor Society Consensus Review for the Practical Recommendations on Glioma Management in Korea.Journal of Korean Neurosurgical Society · 2023Article
- High-dose proton beam therapy versus conventional fractionated radiation therapy for newly diagnosed glioblastoma: a propensity score matching analysis.Radiation oncology (London, England) · 2023Article
- Case Report: Successful treatment of external beam radiation-induced optic papillopathy with intravitreal anti-VEGF.Frontiers in ophthalmology · 2023Article
- [Expert Consensus on the Treatment of Antiangiogenic Agents for Radiation Brain Necrosis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2022Article
- Reactor-based boron neutron capture therapy for 44 cases of recurrent and refractory high-grade meningiomas with long-term follow-up.Neuro-oncology · 2022Article
- Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma.Oncotarget · 2022Article
- Review: Neurological Complications From Therapies for Pediatric Brain Tumors.Frontiers in oncology · 2022Review
- Salvage Surgical Resection after Linac-Based Stereotactic Radiosurgery for Newly Diagnosed Brain Metastasis.Current oncology (Toronto, Ont.) · 2021Article
- Determination of brain tumor recurrence usingCancer science · 2021Article
- Radiation Necrosis from Stereotactic Radiosurgery-How Do We Mitigate?Current treatment options in oncology · 2021Review
- Long-term survival of a patient with diffuse midline glioma in the pineal region: A case report and literature review.Surgical neurology international · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 2 institutions in 1 country.
Motomasa FuruseDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Naosuke NonoguchiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Toshihiko KuroiwaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Susumu MiyamotoDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Yoshiki ArakawaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Jun ShinodaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Kazuhiro MiwaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Toshihiko IuchiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Koji TsuboiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Kiyohiro HoukinDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Shunsuke TerasakaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Yusuke TabeiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Hideo NakamuraDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Motoo NaganeDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Kazuhiko SugiyamaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Mizuhiko TerasakiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Tatsuya AbeDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Yoshitaka NaritaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Nobuhito SaitoDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Akitake MukasaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Kuniaki OgasawaraDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Takaaki BeppuDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Toshihiro KumabeDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Tadashi NariaiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Naohiro TsuyuguchiDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Eiji NakataniDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Shoko KurisuDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Yoko NakagawaDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Shin-Ichi MiyatakeDepartment of Neurosurgery , Osaka Medical College , Takatsuki, Osaka , Japan (M.F., N.N., T.K., S.-I.M.); Department of Neurosurgery , Kyoto University Graduate School of Medicine , Kyoto , Japan (S.M., Y.A.); Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction , Kizawa Memorial Hospital , Minokamo , Japan (J.S., K.M.); Division of Neurological Surgery , Chiba Cancer Center , Chiba , Japan (T.I.); Proton Medical Research Center , University of Tsukuba , Tsukuba , Japan (K.T.); Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan (K.H., S.T.); Department of Neurosurgery , Japanese Red Cross Medical Center , Tokyo , Japan (Y.T.); Department of Neurosurgery , Kumamoto University Graduate School of Medical Science , Kumamoto , Japan (H.N.); Department of Neurosurgery , Kyorin University Faculty of Medicine , Mitaka , Japan (M.N.); Department of Clinical Oncology and Neuro-oncology Program , Hiroshima University Hospital , Hiroshima , Japan (K.S.); Department of Neurosurgery , Kurume University School of Medicine , Kurume , Japan (M.T.); Department of Neurosurgery , Oita University Faculty of Medicine , Oita , Japan (T.A.); Department of Neurosurgery and Neuro-Oncology , National Cancer Center Hospital , Tokyo , Japan (Y.N.); Department of Neurosurgery , The University of Tokyo , Tokyo , Japan (N.S., A.M.); Department of Neurosurgery , Iwate Medical University , Morioka , Japan (K.O.); Department of Neurosurgery, Division of Hyperbaric Medicine , Iwate Medical University , Morioka , Japan (T.B.); Department of Neurosurgery , Kitasato University School of Medicine , Sagamihara , Japan (T.Kum); Department of Neurosurgery , Tokyo Medical and Dental University , Tokyo , Japan (T.N.); Department of Neurosurgery , Osaka City University Graduate School of Medicine , Osaka , Japan (N.T.); Translational Research Informatics Center , Foundation for Biomedical Research and Innovation , Kobe , Japan (E.N., S.K., Y.N.).
Kyoto University · JPOsaka Medical and Pharmaceutical University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain radiation necrosis (BRN) can be a complication of radiotherapy for primary and secondary brain tumors, as well as head and neck tumors. Since vascular endothelial growth factor (VEGF) is also a vascular permeability factor in the brain, bevacizumab, a humanized antibody that inhibits VEGF, would be expected to reduce perilesional edema that often accompanies BRN.
methodsPatients with surgically untreatable, symptomatic BRN refractory to conventional medical treatments (eg, corticosteroid, anticoagulants, or hyperbaric oxygen therapy) were enrolled. We judged that a major cause of perilesional edema with a lesion-to-normal brain ratio ≤1.8 on
resultsOf the 41 patients enrolled, 38 were fully eligible for the response assessment. The primary endpoint was achieved in 30 of the 38 (78.9%) patients at 3.0 months (median) after enrollment. Sixteen patients (42.1%) experienced improvement of their Karnofsy Performance Score. Corticosteroid use could be reduced in 29 patients (76.3%). Adverse events at grade ≥3 occurred in 10 patients (24.4%).
conclusionsBevacizumab treatment offers certain clinical benefits for patients with surgically untreatable, symptomatic BRN. The determination of BRN using amino-acid PET, not biopsy, is adequate and less invasive for determining eligibility to receive bevacizumab.
Indexed as
Bevacizumabbrain radiation necrosispositron emission tomographyvascular endothelial growth factor
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